A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy.
OBJECTIVE: To examine whether the neuropathological and metabolic changes of peripheral nerves are correlated to clinical features in diabetes mellitus type 2 patients with peripheral neuropathy. METHODS: 147 type 2 diabetic patients with signs/symptoms of diabetic peripheralneuropathy (DPN) aged 53...
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doaj-f6f53f5ac5884ce29bb893f559e49f732020-11-25T02:22:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9177210.1371/journal.pone.0091772A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy.Guangren LiChenglin SunYanjun WangYujia LiuXiaokun GangYing GaoFei LiXianchao XiaoGuixia WangOBJECTIVE: To examine whether the neuropathological and metabolic changes of peripheral nerves are correlated to clinical features in diabetes mellitus type 2 patients with peripheral neuropathy. METHODS: 147 type 2 diabetic patients with signs/symptoms of diabetic peripheralneuropathy (DPN) aged 53.4 ± 12.3 years and 134 healthy volunteers aged 55.5 ± 11.7 years were investigated for fasting plasma glucose (FPG), hemoglobin A1C (HbA1c), and red blood cell sorbitol (RBC sorbitol) in addition to nerve conduction velocity (NCV). Among the 147 diabetic patients, 10 patients underwent superficial peroneal nerve biopsy for light and electron microscopy. RESULTS: In the experimental group, the levels of HbA1c and RBC sorbitol showed significant increase compared with the controlled group, whereas motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) both showed decline and SNCV decreased at a greater extent. Morphologically, there were various degrees of nerve fiber loss, associated with axon degeneration and capillary luminal narrowing in 10 patients undergone nerve biopsy. CONCLUSION: The metabolic change of sorbitol, the consequently observed changes in NCV and histopathology of peripheral nerves are positively correlated with the duration of diabetes and overall level of blood glucose.http://europepmc.org/articles/PMC3950272?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guangren Li Chenglin Sun Yanjun Wang Yujia Liu Xiaokun Gang Ying Gao Fei Li Xianchao Xiao Guixia Wang |
spellingShingle |
Guangren Li Chenglin Sun Yanjun Wang Yujia Liu Xiaokun Gang Ying Gao Fei Li Xianchao Xiao Guixia Wang A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy. PLoS ONE |
author_facet |
Guangren Li Chenglin Sun Yanjun Wang Yujia Liu Xiaokun Gang Ying Gao Fei Li Xianchao Xiao Guixia Wang |
author_sort |
Guangren Li |
title |
A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy. |
title_short |
A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy. |
title_full |
A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy. |
title_fullStr |
A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy. |
title_full_unstemmed |
A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy. |
title_sort |
clinical and neuropathological study of chinese patients with diabetic peripheral neuropathy. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
OBJECTIVE: To examine whether the neuropathological and metabolic changes of peripheral nerves are correlated to clinical features in diabetes mellitus type 2 patients with peripheral neuropathy. METHODS: 147 type 2 diabetic patients with signs/symptoms of diabetic peripheralneuropathy (DPN) aged 53.4 ± 12.3 years and 134 healthy volunteers aged 55.5 ± 11.7 years were investigated for fasting plasma glucose (FPG), hemoglobin A1C (HbA1c), and red blood cell sorbitol (RBC sorbitol) in addition to nerve conduction velocity (NCV). Among the 147 diabetic patients, 10 patients underwent superficial peroneal nerve biopsy for light and electron microscopy. RESULTS: In the experimental group, the levels of HbA1c and RBC sorbitol showed significant increase compared with the controlled group, whereas motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) both showed decline and SNCV decreased at a greater extent. Morphologically, there were various degrees of nerve fiber loss, associated with axon degeneration and capillary luminal narrowing in 10 patients undergone nerve biopsy. CONCLUSION: The metabolic change of sorbitol, the consequently observed changes in NCV and histopathology of peripheral nerves are positively correlated with the duration of diabetes and overall level of blood glucose. |
url |
http://europepmc.org/articles/PMC3950272?pdf=render |
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