Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry
Abstract Background: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical elec...
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2018-06-01
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doaj-f6fd0c90f36a406d8ad0837eafbefc3e2020-11-24T22:08:19ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-41702018-06-01010.5935/abc.20180094S0066-782X2018005007102Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year RegistryStefan Warpechowski NetoTiago Luiz Luz LeiriaLaura Lessa Gaudie LeyAntonio Lessa Gaudie LeyLuiza Zwan DutraLeonardo Martins PiresMarcelo Lapa KruseGustavo Glotz de LimaAbstract Background: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. Objective: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center. Methods: Cohort study of patients referred for electrophysiological study because of an ECG pattern compatible with SBr between January 1998 and March 2017. Results: Of the 5506 procedures, 35 (0.64%) were for SBr investigation, 25 of which (71.42%) were performed in men. The mean age was 43.89 ± 13.1 years. The ECG patterns were as follows: type I, 22 (62.85%); type II, 12 (34.30%); and type III, 1 (2.85%). Twenty-three patients (65.7%) were asymptomatic, 6 (17.14%) had palpitations, 5 (14.3%) had syncope, and 3 (8.6%) had a family history of sudden death. Electrophysiological study induced ventricular tachyarrhythmias in 16 cases (45.7%), the mean ventricular refractory period being 228 ± 36 ms. Ajmaline / procainamide was used in 11 cases (31.4%), changing the ECG pattern to type I in 7 (63.6%). Sixteen cases (45.7%) received an implantable cardioverter defibrillator (ICD). In a mean 5-year follow-up, 1 of the 16 patients (6.25%) with ICD had appropriate therapy for ventricular fibrillation. There was no death. Other arrhythmias occurred in 4 (11.4%) cases. Conclusions: Most patients are men, and a type I ECG pattern is the main indication for electrophysiological study. Class IA drugs have a high ECG conversion rate. The ICD event rate was 6%. (Arq Bras Cardiol. 2018; [online].ahead print, PP.0-0)http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018005007102&lng=en&tlng=enBrugada SyndromeVentricular TachycardiaSudden Death |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefan Warpechowski Neto Tiago Luiz Luz Leiria Laura Lessa Gaudie Ley Antonio Lessa Gaudie Ley Luiza Zwan Dutra Leonardo Martins Pires Marcelo Lapa Kruse Gustavo Glotz de Lima |
spellingShingle |
Stefan Warpechowski Neto Tiago Luiz Luz Leiria Laura Lessa Gaudie Ley Antonio Lessa Gaudie Ley Luiza Zwan Dutra Leonardo Martins Pires Marcelo Lapa Kruse Gustavo Glotz de Lima Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry Arquivos Brasileiros de Cardiologia Brugada Syndrome Ventricular Tachycardia Sudden Death |
author_facet |
Stefan Warpechowski Neto Tiago Luiz Luz Leiria Laura Lessa Gaudie Ley Antonio Lessa Gaudie Ley Luiza Zwan Dutra Leonardo Martins Pires Marcelo Lapa Kruse Gustavo Glotz de Lima |
author_sort |
Stefan Warpechowski Neto |
title |
Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry |
title_short |
Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry |
title_full |
Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry |
title_fullStr |
Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry |
title_full_unstemmed |
Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry |
title_sort |
cohort of patients referred for brugada syndrome investigation in an electrophysiology service - 19-year registry |
publisher |
Sociedade Brasileira de Cardiologia (SBC) |
series |
Arquivos Brasileiros de Cardiologia |
issn |
1678-4170 |
publishDate |
2018-06-01 |
description |
Abstract Background: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. Objective: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center. Methods: Cohort study of patients referred for electrophysiological study because of an ECG pattern compatible with SBr between January 1998 and March 2017. Results: Of the 5506 procedures, 35 (0.64%) were for SBr investigation, 25 of which (71.42%) were performed in men. The mean age was 43.89 ± 13.1 years. The ECG patterns were as follows: type I, 22 (62.85%); type II, 12 (34.30%); and type III, 1 (2.85%). Twenty-three patients (65.7%) were asymptomatic, 6 (17.14%) had palpitations, 5 (14.3%) had syncope, and 3 (8.6%) had a family history of sudden death. Electrophysiological study induced ventricular tachyarrhythmias in 16 cases (45.7%), the mean ventricular refractory period being 228 ± 36 ms. Ajmaline / procainamide was used in 11 cases (31.4%), changing the ECG pattern to type I in 7 (63.6%). Sixteen cases (45.7%) received an implantable cardioverter defibrillator (ICD). In a mean 5-year follow-up, 1 of the 16 patients (6.25%) with ICD had appropriate therapy for ventricular fibrillation. There was no death. Other arrhythmias occurred in 4 (11.4%) cases. Conclusions: Most patients are men, and a type I ECG pattern is the main indication for electrophysiological study. Class IA drugs have a high ECG conversion rate. The ICD event rate was 6%. (Arq Bras Cardiol. 2018; [online].ahead print, PP.0-0) |
topic |
Brugada Syndrome Ventricular Tachycardia Sudden Death |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018005007102&lng=en&tlng=en |
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