Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms

Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms

Since its inception, the coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), as it is the viral source of COVID-19. Alkaloids are o...

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Main Authors: Mohammad Bagher Majnooni, Sajad Fakhri, Gholamreza Bahrami, Maryam Naseri, Mohammad Hosein Farzaei, Javier Echeverría
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2021/6632623
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spelling doaj-f70954d2157b421190b4b644f437879e2021-05-31T00:33:31ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-42882021-01-01202110.1155/2021/6632623Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal MechanismsMohammad Bagher Majnooni0Sajad Fakhri1Gholamreza Bahrami2Maryam Naseri3Mohammad Hosein Farzaei4Javier Echeverría5Student Research CommitteePharmaceutical Sciences Research CenterPharmaceutical Sciences Research CenterPharmaceutical Sciences Research CenterPharmaceutical Sciences Research CenterDepartamento de Ciencias del AmbienteSince its inception, the coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), as it is the viral source of COVID-19. Alkaloids are one of the most widespread plant-derived natural compounds with prominent antiviral effects. Accordingly, these phytochemicals have been promising candidates towards discovering effective treatments for COVID-19. Alkaloids have shown potential anti-SARS-CoV activities via inhibiting pathogenesis-associated targets of the Coronaviridae family that are required for the virus life cycle. In the current study, the chemistry, plant sources, and antiviral effects of alkaloids, as well as their anti-SARS-CoV-2 effect with related mechanisms, are reviewed towards discovering an effective treatment against COVID-19.http://dx.doi.org/10.1155/2021/6632623
collection DOAJ
language English
format Article
sources DOAJ
author Mohammad Bagher Majnooni
Sajad Fakhri
Gholamreza Bahrami
Maryam Naseri
Mohammad Hosein Farzaei
Javier Echeverría
spellingShingle Mohammad Bagher Majnooni
Sajad Fakhri
Gholamreza Bahrami
Maryam Naseri
Mohammad Hosein Farzaei
Javier Echeverría
Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms
Evidence-Based Complementary and Alternative Medicine
author_facet Mohammad Bagher Majnooni
Sajad Fakhri
Gholamreza Bahrami
Maryam Naseri
Mohammad Hosein Farzaei
Javier Echeverría
author_sort Mohammad Bagher Majnooni
title Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms
title_short Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms
title_full Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms
title_fullStr Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms
title_full_unstemmed Alkaloids as Potential Phytochemicals against SARS-CoV-2: Approaches to the Associated Pivotal Mechanisms
title_sort alkaloids as potential phytochemicals against sars-cov-2: approaches to the associated pivotal mechanisms
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-4288
publishDate 2021-01-01
description Since its inception, the coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), as it is the viral source of COVID-19. Alkaloids are one of the most widespread plant-derived natural compounds with prominent antiviral effects. Accordingly, these phytochemicals have been promising candidates towards discovering effective treatments for COVID-19. Alkaloids have shown potential anti-SARS-CoV activities via inhibiting pathogenesis-associated targets of the Coronaviridae family that are required for the virus life cycle. In the current study, the chemistry, plant sources, and antiviral effects of alkaloids, as well as their anti-SARS-CoV-2 effect with related mechanisms, are reviewed towards discovering an effective treatment against COVID-19.
url http://dx.doi.org/10.1155/2021/6632623
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