Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins

Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins

Pneumonia is a leading cause of death in children and the elderly worldwide, accounting for 15% of all deaths of children under 5 years old. Streptococcus pneumoniae is a common and aggressive cause of pneumonia and can also contribute to meningitis and sepsis. Despite the widespread use of antibiot...

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Bibliographic Details
Main Authors: Xueyi Li, Yanfang Yu, Boris Gorshkov, Stephen Haigh, Zsuzsanna Bordan, Daniel Weintraub, Radu Daniel Rudic, Trinad Chakraborty, Scott A. Barman, Alexander D. Verin, Yunchao Su, Rudolf Lucas, David W. Stepp, Feng Chen, David J. R. Fulton
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
pneumolysin
endothelial barrier
reactive oxygen species
mitochondria
Hsp70
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01309/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01309/full

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