Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment
Despite the benefit of early cancer screening, Japan has one of the lowest cancer screening rates among developed countries, possibly due to there being a lack of “a good test” that can provide sufficient levels of test sensitivity and accuracy without a large price tag. As a number of essential and...
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doaj-f714fa99df3b40cb9ccf9e634a7ff2a82021-10-06T15:05:11ZengPeerJ Inc.PeerJ2167-83592021-10-019e1224710.7717/peerj.12247Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessmentMiho Kusakabe0Masahiro Sato1Yohko Nakamura2Haruo Mikami3Jason Lin4Hiroki Nagase5Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, JapanCancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, JapanCancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, JapanCancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, JapanDivision of Clinical Genomics, Chiba Cancer Center Research Institute, Chiba, JapanGraduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, JapanDespite the benefit of early cancer screening, Japan has one of the lowest cancer screening rates among developed countries, possibly due to there being a lack of “a good test” that can provide sufficient levels of test sensitivity and accuracy without a large price tag. As a number of essential and trace elements have been intimately connected to the oncogenesis of cancer, Metallobalance, a recent development in elemental analysis utilizing the technique of inductively coupled plasma mass spectrometry has been developed and tested as a robust method for arrayed cancer risk screening. We have conducted case-control epidemiological studies in the prefecture of Chiba, in the Greater Tokyo Area, and sought to determine both Metallobalance screening’s effectiveness for predicting pan-cancer outcomes, and whether the method is capable enough to replace the more conventional antigen-based testing methods. Results suggest that MB screening provides some means of classification potential among cancer and non-cancer cases, and may work well as a complementary method to traditional antigen-based tumor marker testing, even in situations where tumor markers alone cannot discernibly identify cancer from non-cancer cases.https://peerj.com/articles/12247.pdfCancer biologyChemical biologyEpidemiologyMass spectrometryPreventative medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miho Kusakabe Masahiro Sato Yohko Nakamura Haruo Mikami Jason Lin Hiroki Nagase |
spellingShingle |
Miho Kusakabe Masahiro Sato Yohko Nakamura Haruo Mikami Jason Lin Hiroki Nagase Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment PeerJ Cancer biology Chemical biology Epidemiology Mass spectrometry Preventative medicine |
author_facet |
Miho Kusakabe Masahiro Sato Yohko Nakamura Haruo Mikami Jason Lin Hiroki Nagase |
author_sort |
Miho Kusakabe |
title |
Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment |
title_short |
Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment |
title_full |
Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment |
title_fullStr |
Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment |
title_full_unstemmed |
Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment |
title_sort |
elemental analysis by metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2021-10-01 |
description |
Despite the benefit of early cancer screening, Japan has one of the lowest cancer screening rates among developed countries, possibly due to there being a lack of “a good test” that can provide sufficient levels of test sensitivity and accuracy without a large price tag. As a number of essential and trace elements have been intimately connected to the oncogenesis of cancer, Metallobalance, a recent development in elemental analysis utilizing the technique of inductively coupled plasma mass spectrometry has been developed and tested as a robust method for arrayed cancer risk screening. We have conducted case-control epidemiological studies in the prefecture of Chiba, in the Greater Tokyo Area, and sought to determine both Metallobalance screening’s effectiveness for predicting pan-cancer outcomes, and whether the method is capable enough to replace the more conventional antigen-based testing methods. Results suggest that MB screening provides some means of classification potential among cancer and non-cancer cases, and may work well as a complementary method to traditional antigen-based tumor marker testing, even in situations where tumor markers alone cannot discernibly identify cancer from non-cancer cases. |
topic |
Cancer biology Chemical biology Epidemiology Mass spectrometry Preventative medicine |
url |
https://peerj.com/articles/12247.pdf |
work_keys_str_mv |
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