Half Uniformity dosage of Metformin hydrocloride in tablets of different brands
Metformin is one of the most prescribed medications in the world for the treatment of type 2 diabetes mellitus. The professional experience with the use of a drug Metformin shown to be very effective in lowering plasma glucose. The practice of cutting through the tablet Metformin has been a widely...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Universidade Federal de Rondonópolis
2016-05-01
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Series: | Scientific Electronic Archives |
Subjects: | |
Online Access: | http://www.seasinop.com.br/revista/index.php?journal=SEA&page=article&op=view&path%5B%5D=263&path%5B%5D=pdf_96 |
Summary: | Metformin is one of the most prescribed medications in the world for the treatment of type 2 diabetes
mellitus. The professional experience with the use of a drug Metformin shown to be very effective in lowering plasma
glucose. The practice of cutting through the tablet Metformin has been a widely used technique and is justified for
obtaining the prescribed dose, because often not be found commercially and is sometimes also related to cost reduction.
In most cases this is done regardless of circulation groove present in the tablet and the manufacturer's
recommendations. The aim of this study was to analyze the content of active ingredient available in half tablet being
looked after partition, made through the cutter pills. The values of uniformity half dose of Metformin were irregular, not
following the values that theoretically should be included, in other words 425mg or 100% active ingredient and are
therefore considered bad. Compared with the three laboratories, A presented the best results, with an average
percentage of active principle of 98.72%. Already presented the worst result was the lab C, mean percentage of active
principle of 73.33%, below the lab B, mean percentage of active principle of 121.40%. Best results obtained by A and B
are due to the groove divider these tablets, the tablets had no laboratory C. The results obtained in this work show that
despite the laboratory, the practice of cutting the pill should not be performed due to the high level differences in the half
dosage. This compromises the effectiveness of therapy and safe treatment, and numerous times this practice is
recommended by medical practitioners and professionals health.
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ISSN: | 2316-9281 2316-9281 |