Renal catabolism of albumin – current views and controversies
Albumin is the main protein of blood plasma, lymph, cerebrospinal fluid and interstitial fluid. The protein assists in many important body functions, including maintenance of proper colloidal osmotic pressure, transport of important metabolites and antioxidant action. Synthesis of albumin takes plac...
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Index Copernicus International S.A.
2011-10-01
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doaj-f7189ea771c8438da4f1ef3aee8a953f2020-11-25T00:54:22ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932011-10-0165846636668677Renal catabolism of albumin – current views and controversiesJakub GburekKrzysztof GołąbKatarzyna JuszczyńskaAlbumin is the main protein of blood plasma, lymph, cerebrospinal fluid and interstitial fluid. The protein assists in many important body functions, including maintenance of proper colloidal osmotic pressure, transport of important metabolites and antioxidant action. Synthesis of albumin takes place mainly in the liver, and its catabolism occurs mostly in vascular endothelium of muscle, skin and liver as well as in the kidney tubular epithelium. Renal catabolism of albumin consists of glomerular filtration and tubular reabsorption. The tubular processes include endocytosis via the multiligand scavenger receptor tandem megalin and cubilin-amnionless complex. Possible ways of further catabolism of this protein are lysosomal proteolysis to amino acids and short peptides, recycling of degradation products into the bloodstream and tubular lumen or transcytosis of whole molecules. The article discusses the molecular aspects of these processes and presents the controversies arising in the light of the last decade of research.http://journals.indexcopernicus.com/fulltxt.php?ICID=964329albuminanerkowy katabolizm białekkanalik proksymalny nerkiProteinuriamegalinakubilina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jakub Gburek Krzysztof Gołąb Katarzyna Juszczyńska |
spellingShingle |
Jakub Gburek Krzysztof Gołąb Katarzyna Juszczyńska Renal catabolism of albumin – current views and controversies Postępy Higieny i Medycyny Doświadczalnej albumina nerkowy katabolizm białek kanalik proksymalny nerki Proteinuria megalina kubilina |
author_facet |
Jakub Gburek Krzysztof Gołąb Katarzyna Juszczyńska |
author_sort |
Jakub Gburek |
title |
Renal catabolism of albumin – current views and controversies |
title_short |
Renal catabolism of albumin – current views and controversies |
title_full |
Renal catabolism of albumin – current views and controversies |
title_fullStr |
Renal catabolism of albumin – current views and controversies |
title_full_unstemmed |
Renal catabolism of albumin – current views and controversies |
title_sort |
renal catabolism of albumin – current views and controversies |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2011-10-01 |
description |
Albumin is the main protein of blood plasma, lymph, cerebrospinal fluid and interstitial fluid. The protein assists in many important body functions, including maintenance of proper colloidal osmotic pressure, transport of important metabolites and antioxidant action. Synthesis of albumin takes place mainly in the liver, and its catabolism occurs mostly in vascular endothelium of muscle, skin and liver as well as in the kidney tubular epithelium. Renal catabolism of albumin consists of glomerular filtration and tubular reabsorption. The tubular processes include endocytosis via the multiligand scavenger receptor tandem megalin and cubilin-amnionless complex. Possible ways of further catabolism of this protein are lysosomal proteolysis to amino acids and short peptides, recycling of degradation products into the bloodstream and tubular lumen or transcytosis of whole molecules. The article discusses the molecular aspects of these processes and presents the controversies arising in the light of the last decade of research. |
topic |
albumina nerkowy katabolizm białek kanalik proksymalny nerki Proteinuria megalina kubilina |
url |
http://journals.indexcopernicus.com/fulltxt.php?ICID=964329 |
work_keys_str_mv |
AT jakubgburek renalcatabolismofalbumincurrentviewsandcontroversies AT krzysztofgołab renalcatabolismofalbumincurrentviewsandcontroversies AT katarzynajuszczynska renalcatabolismofalbumincurrentviewsandcontroversies |
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1725234494125899776 |