PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES
This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleosides, a new class of interesting and potentially antiviral/antitumor agents. The synthetic methodology relies on a 1,3-dipolar cycloaddition reaction as a key step. The cycloaddition process involves substituted...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associazione Italiana Giovani Medici
2014-04-01
|
| Series: | Euromediterranean Biomedical Journal |
| Online Access: | http://www.embj.org/images/ISSUE_2014/giofre_7.pdf |
| id |
doaj-f71bcca04e7f476793a3d7e379129a9b |
|---|---|
| record_format |
Article |
| spelling |
doaj-f71bcca04e7f476793a3d7e379129a9b2020-11-24T23:27:05ZengAssociazione Italiana Giovani MediciEuromediterranean Biomedical Journal2279-71652279-71652014-04-0197455510.3269/1970-5492.2014.9.7PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDESSalvatore Giofrè0University of MessinaThis review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleosides, a new class of interesting and potentially antiviral/antitumor agents. The synthetic methodology relies on a 1,3-dipolar cycloaddition reaction as a key step. The cycloaddition process involves substituted nitrones, phosphonated nitrones, or nitrones containing functional groups easily convertible into a phosphonated group. Biological assays are presented, which show that phosphonated isoxazolidinyl nucleosides represent a new promising template of nucleoside analogues. http://www.embj.org/images/ISSUE_2014/giofre_7.pdf |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Salvatore Giofrè |
| spellingShingle |
Salvatore Giofrè PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES Euromediterranean Biomedical Journal |
| author_facet |
Salvatore Giofrè |
| author_sort |
Salvatore Giofrè |
| title |
PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES |
| title_short |
PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES |
| title_full |
PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES |
| title_fullStr |
PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES |
| title_full_unstemmed |
PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES |
| title_sort |
phosphonated isoxazolidinyl nucleosides, a new class of modified nucleosides |
| publisher |
Associazione Italiana Giovani Medici |
| series |
Euromediterranean Biomedical Journal |
| issn |
2279-7165 2279-7165 |
| publishDate |
2014-04-01 |
| description |
This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleosides,
a new class of interesting and potentially antiviral/antitumor agents. The synthetic
methodology relies on a 1,3-dipolar cycloaddition reaction as a key step. The cycloaddition
process involves substituted nitrones, phosphonated nitrones, or nitrones containing
functional groups easily convertible into a phosphonated group. Biological assays are presented,
which show that phosphonated isoxazolidinyl nucleosides represent a new promising
template of nucleoside analogues.
|
| url |
http://www.embj.org/images/ISSUE_2014/giofre_7.pdf |
| work_keys_str_mv |
AT salvatoregiofre phosphonatedisoxazolidinylnucleosidesanewclassofmodifiednucleosides |
| _version_ |
1725553413619449856 |