Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease

The pathogenesis of Parkinson’s disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial intracellular physiological processes. Importantly, in addition to abnormal α-synuclein aggregation, the dysfunction of various mitoch...

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Main Authors:	Lara Sironi, Lisa Michelle Restelli, Markus Tolnay, Albert Neutzner, Stephan Frank
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Cells
Subjects:	α-syn lrrk2 dj-1 parkin pink1 atp13a2 vps35 mam mitophagy neurodegeneration
Online Access:	https://www.mdpi.com/2073-4409/9/1/233

id	doaj-f71bdf935cbb4fb18b1438e49bb4b651
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spelling	doaj-f71bdf935cbb4fb18b1438e49bb4b6512020-11-25T01:42:36ZengMDPI AGCells2073-44092020-01-019123310.3390/cells9010233cells9010233Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s DiseaseLara Sironi0Lisa Michelle Restelli1Markus Tolnay2Albert Neutzner3Stephan Frank4Division of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, SwitzerlandDivision of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, SwitzerlandDivision of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, SwitzerlandDepartment of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, SwitzerlandDivision of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, SwitzerlandThe pathogenesis of Parkinson’s disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial intracellular physiological processes. Importantly, in addition to abnormal α-synuclein aggregation, the dysfunction of various mitochondria-dependent processes has been prominently implicated in PD pathogenesis. Besides the long-known loss of the organelles’ bioenergetics function resulting in diminished ATP synthesis, more recent studies in the field have increasingly focused on compromised mitochondrial quality control as well as impaired biochemical processes specifically localized to ER−mitochondria interfaces (such as lipid biosynthesis and calcium homeostasis). In this review, we will discuss how dysregulated mitochondrial crosstalk with other organelles contributes to PD pathogenesis.https://www.mdpi.com/2073-4409/9/1/233α-synlrrk2dj-1parkinpink1atp13a2vps35mammitophagyneurodegeneration
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lara Sironi Lisa Michelle Restelli Markus Tolnay Albert Neutzner Stephan Frank
spellingShingle	Lara Sironi Lisa Michelle Restelli Markus Tolnay Albert Neutzner Stephan Frank Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease Cells α-syn lrrk2 dj-1 parkin pink1 atp13a2 vps35 mam mitophagy neurodegeneration
author_facet	Lara Sironi Lisa Michelle Restelli Markus Tolnay Albert Neutzner Stephan Frank
author_sort	Lara Sironi
title	Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease
title_short	Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease
title_full	Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease
title_fullStr	Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease
title_full_unstemmed	Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease
title_sort	dysregulated interorganellar crosstalk of mitochondria in the pathogenesis of parkinson’s disease
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2020-01-01
description	The pathogenesis of Parkinson’s disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial intracellular physiological processes. Importantly, in addition to abnormal α-synuclein aggregation, the dysfunction of various mitochondria-dependent processes has been prominently implicated in PD pathogenesis. Besides the long-known loss of the organelles’ bioenergetics function resulting in diminished ATP synthesis, more recent studies in the field have increasingly focused on compromised mitochondrial quality control as well as impaired biochemical processes specifically localized to ER−mitochondria interfaces (such as lipid biosynthesis and calcium homeostasis). In this review, we will discuss how dysregulated mitochondrial crosstalk with other organelles contributes to PD pathogenesis.
topic	α-syn lrrk2 dj-1 parkin pink1 atp13a2 vps35 mam mitophagy neurodegeneration
url	https://www.mdpi.com/2073-4409/9/1/233
work_keys_str_mv	AT larasironi dysregulatedinterorganellarcrosstalkofmitochondriainthepathogenesisofparkinsonsdisease AT lisamichellerestelli dysregulatedinterorganellarcrosstalkofmitochondriainthepathogenesisofparkinsonsdisease AT markustolnay dysregulatedinterorganellarcrosstalkofmitochondriainthepathogenesisofparkinsonsdisease AT albertneutzner dysregulatedinterorganellarcrosstalkofmitochondriainthepathogenesisofparkinsonsdisease AT stephanfrank dysregulatedinterorganellarcrosstalkofmitochondriainthepathogenesisofparkinsonsdisease
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Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease

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