Mechanisms of eosinophil cytokine release
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The loca...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2005-03-01
|
Series: | Memórias do Instituto Oswaldo Cruz. |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900013 |
id |
doaj-f727fbfb9e9e4cecb9543d304121d1a8 |
---|---|
record_format |
Article |
spelling |
doaj-f727fbfb9e9e4cecb9543d304121d1a82020-11-24T22:06:30ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80602005-03-01100738110.1590/S0074-02762005000900013Mechanisms of eosinophil cytokine releaseChristianne Bandeira-MeloPeter F WellerHuman eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900013eosinophilscytokinesdegranulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christianne Bandeira-Melo Peter F Weller |
spellingShingle |
Christianne Bandeira-Melo Peter F Weller Mechanisms of eosinophil cytokine release Memórias do Instituto Oswaldo Cruz. eosinophils cytokines degranulation |
author_facet |
Christianne Bandeira-Melo Peter F Weller |
author_sort |
Christianne Bandeira-Melo |
title |
Mechanisms of eosinophil cytokine release |
title_short |
Mechanisms of eosinophil cytokine release |
title_full |
Mechanisms of eosinophil cytokine release |
title_fullStr |
Mechanisms of eosinophil cytokine release |
title_full_unstemmed |
Mechanisms of eosinophil cytokine release |
title_sort |
mechanisms of eosinophil cytokine release |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
2005-03-01 |
description |
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity. |
topic |
eosinophils cytokines degranulation |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900013 |
work_keys_str_mv |
AT christiannebandeiramelo mechanismsofeosinophilcytokinerelease AT peterfweller mechanismsofeosinophilcytokinerelease |
_version_ |
1725823419202666496 |