Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
It is currently unclear how quantitative changes in chromatin loop propensity contribute to differential gene regulation. Here, the authors use phased Hi-C, RNA-seq, and ChIP-seq to show that subtle changes in loop propensity associate with differential gene regulation across cell types and haplotyp...
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2019-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-08940-5 |
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doaj-f72b1213a233451aa67b2d6cb89c60be2021-05-11T12:11:36ZengNature Publishing GroupNature Communications2041-17232019-03-0110111710.1038/s41467-019-08940-5Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expressionWilliam W. Greenwald0He Li1Paola Benaglio2David Jakubosky3Hiroko Matsui4Anthony Schmitt5Siddarth Selvaraj6Matteo D’Antonio7Agnieszka D’Antonio-Chronowska8Erin N. Smith9Kelly A. Frazer10Bioinformatics and Systems Biology Graduate Program, University of California, San DiegoInstitute for Genomic Medicine, University of California, San DiegoDepartment of Pediatrics and Rady Children’s Hospital, University of California, San DiegoBiomedical Sciences Graduate Program, University of California, San DiegoInstitute for Genomic Medicine, University of California, San DiegoArima GenomicsArima GenomicsInstitute for Genomic Medicine, University of California, San DiegoInstitute for Genomic Medicine, University of California, San DiegoDepartment of Pediatrics and Rady Children’s Hospital, University of California, San DiegoInstitute for Genomic Medicine, University of California, San DiegoIt is currently unclear how quantitative changes in chromatin loop propensity contribute to differential gene regulation. Here, the authors use phased Hi-C, RNA-seq, and ChIP-seq to show that subtle changes in loop propensity associate with differential gene regulation across cell types and haplotypes.https://doi.org/10.1038/s41467-019-08940-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
William W. Greenwald He Li Paola Benaglio David Jakubosky Hiroko Matsui Anthony Schmitt Siddarth Selvaraj Matteo D’Antonio Agnieszka D’Antonio-Chronowska Erin N. Smith Kelly A. Frazer |
spellingShingle |
William W. Greenwald He Li Paola Benaglio David Jakubosky Hiroko Matsui Anthony Schmitt Siddarth Selvaraj Matteo D’Antonio Agnieszka D’Antonio-Chronowska Erin N. Smith Kelly A. Frazer Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression Nature Communications |
author_facet |
William W. Greenwald He Li Paola Benaglio David Jakubosky Hiroko Matsui Anthony Schmitt Siddarth Selvaraj Matteo D’Antonio Agnieszka D’Antonio-Chronowska Erin N. Smith Kelly A. Frazer |
author_sort |
William W. Greenwald |
title |
Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression |
title_short |
Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression |
title_full |
Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression |
title_fullStr |
Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression |
title_full_unstemmed |
Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression |
title_sort |
subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-03-01 |
description |
It is currently unclear how quantitative changes in chromatin loop propensity contribute to differential gene regulation. Here, the authors use phased Hi-C, RNA-seq, and ChIP-seq to show that subtle changes in loop propensity associate with differential gene regulation across cell types and haplotypes. |
url |
https://doi.org/10.1038/s41467-019-08940-5 |
work_keys_str_mv |
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