Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.

Invasive aspergillosis (IA) due to Aspergillus fumigatus is a major cause of mortality in immunocompromised patients. The discovery of highly fertile strains of A. fumigatus opened the possibility to merge classical and contemporary genetics to address key questions about this pathogen. The merger i...

Full description

Bibliographic Details
Main Authors: Liliana Losada, Janyce A Sugui, Michael A Eckhaus, Yun C Chang, Stephanie Mounaud, Abigail Figat, Vinita Joardar, Suman B Pakala, Suchitra Pakala, Pratap Venepally, Natalie Fedorova, William C Nierman, Kyung J Kwon-Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4409388?pdf=render

Similar Items

Similar Items