Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic Review
Objective: The aim of this study was to evaluate the prognostic factors of recurrence in uterine tumors resembling ovarian sex-cord tumors (UTROSCT) and to determine clinical-pathological characteristics, treatment options and outcome. Material and Method: An electronic literature search was conduc...
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Federation of Turkish Pathology Societies
2018-09-01
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doaj-f73e4ad352a6499ea99ae6d814dca21b2020-11-24T20:43:51ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302018-09-0134322523310.5146/tjpath.2018.01429Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic ReviewGünsu KIMYON CÖMERTÇiğdem KILIÇDeniz ÇAVUŞOĞLUOsman TÜRKMENAlper KARALOKTaner TURANDerman BAŞARANNurettin BORANObjective: The aim of this study was to evaluate the prognostic factors of recurrence in uterine tumors resembling ovarian sex-cord tumors (UTROSCT) and to determine clinical-pathological characteristics, treatment options and outcome. Material and Method: An electronic literature search was conducted from 1976 to 2018. After the comprehensive evaluation and conjunction with our case, the study included 79 cases. Results: The median age at initial diagnosis was 49 years (range; 16-86 years). The age was under 40 years in 21 (26.6%) patients. Whereas 68 patients underwent at least hysterectomy, 9 patients had organ sparing surgery. There was necrosis in 4 (5.1%) patients, atypia in 16 (20.3%) patients, and infiltrative tumor border in 34 (43%) patients. At least one mitosis per 10 high power fields was determined in 36 (45.5%) patients. The tumor involved at least part of the myometrium in 54 (68.3%) patients. Median follow-up time was 30 months (range; 3-296 months). Recurrence was determined in 5 (6.3%) patients. The disease free survival (DFS) was significantly related only to surgery type. None of the pathologic features were associated with DFS. The 5-year DFS was 86% and 96% in patients who underwent organ sparing surgery or not, respectively (p=0.038). Conclusion: The accurate pathologic diagnosis of UTROSCT has great value in shaping surgical management and management during the follow-up period. Organ sparing surgery was related to poor DFS. Although recurrence is rare, it should be kept in mind for patients with UTROSCT. http://www.turkjpath.org/pdf.php3?id=1867 Uterine neoplasmsRecurrenceUTROSCTSurgeryPrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Günsu KIMYON CÖMERT Çiğdem KILIÇ Deniz ÇAVUŞOĞLU Osman TÜRKMEN Alper KARALOK Taner TURAN Derman BAŞARAN Nurettin BORAN |
spellingShingle |
Günsu KIMYON CÖMERT Çiğdem KILIÇ Deniz ÇAVUŞOĞLU Osman TÜRKMEN Alper KARALOK Taner TURAN Derman BAŞARAN Nurettin BORAN Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic Review Türk Patoloji Dergisi Uterine neoplasms Recurrence UTROSCT Surgery Prognosis |
author_facet |
Günsu KIMYON CÖMERT Çiğdem KILIÇ Deniz ÇAVUŞOĞLU Osman TÜRKMEN Alper KARALOK Taner TURAN Derman BAŞARAN Nurettin BORAN |
author_sort |
Günsu KIMYON CÖMERT |
title |
Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic Review |
title_short |
Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic Review |
title_full |
Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic Review |
title_fullStr |
Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic Review |
title_full_unstemmed |
Recurrence in Uterine Tumors with Ovarian Sex-Cord Tumor Resemblance: A Case Report and Systematic Review |
title_sort |
recurrence in uterine tumors with ovarian sex-cord tumor resemblance: a case report and systematic review |
publisher |
Federation of Turkish Pathology Societies |
series |
Türk Patoloji Dergisi |
issn |
1018-5615 1309-5730 |
publishDate |
2018-09-01 |
description |
Objective: The aim of this study was to evaluate the prognostic factors of recurrence in uterine tumors resembling ovarian sex-cord tumors (UTROSCT) and to determine clinical-pathological characteristics, treatment options and outcome.
Material and Method: An electronic literature search was conducted from 1976 to 2018. After the comprehensive evaluation and conjunction with our case, the study included 79 cases.
Results: The median age at initial diagnosis was 49 years (range; 16-86 years). The age was under 40 years in 21 (26.6%) patients. Whereas 68 patients underwent at least hysterectomy, 9 patients had organ sparing surgery. There was necrosis in 4 (5.1%) patients, atypia in 16 (20.3%) patients, and infiltrative tumor border in 34 (43%) patients. At least one mitosis per 10 high power fields was determined in 36 (45.5%) patients. The tumor involved at least part of the myometrium in 54 (68.3%) patients. Median follow-up time was 30 months (range; 3-296 months). Recurrence was determined in 5 (6.3%) patients. The disease free survival (DFS) was significantly related only to surgery type. None of the pathologic features were associated with DFS. The 5-year DFS was 86% and 96% in patients who underwent organ sparing surgery or not, respectively (p=0.038).
Conclusion: The accurate pathologic diagnosis of UTROSCT has great value in shaping surgical management and management during the follow-up period. Organ sparing surgery was related to poor DFS. Although recurrence is rare, it should be kept in mind for patients with UTROSCT. |
topic |
Uterine neoplasms Recurrence UTROSCT Surgery Prognosis |
url |
http://www.turkjpath.org/pdf.php3?id=1867
|
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