Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study
Adherence with antiretroviral therapy is important for preventing disease progression and HIV transmission. The co‐encapsulated pill sensor system sends a signal through a cutaneous patch and allows real‐time monitoring of pill ingestion. A 16‐week pilot study used a sensor system in 15 HIV‐infected...
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Series: | Clinical and Translational Science |
Online Access: | https://doi.org/10.1111/cts.12701 |
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doaj-f73fc6bb95ac4609902d10775af626a02020-11-25T01:53:18ZengWileyClinical and Translational Science1752-80541752-80622020-01-0113118919410.1111/cts.12701Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot StudyEric S. Daar0Marc I. Rosen1Yan Wang2Lisa Siqueiros3Jie Shen4Mario Guerrero5Di Xiong6John Dao7Todd Young8Katya Corado9Courtney V. Fletcher10Honghu Liu11Los Angeles Biomedical Research Institute at Harbor‐University of California Los Angeles (UCLA) Medical Center Torrance California USASchool of Medicine Yale University New Haven Connecticut USAFielding School of Public Health UCLA Los Angeles California USALos Angeles Biomedical Research Institute at Harbor‐University of California Los Angeles (UCLA) Medical Center Torrance California USASchool of Dentistry University of California, Los Angeles (UCLA) Los Angeles California USALos Angeles Biomedical Research Institute at Harbor‐University of California Los Angeles (UCLA) Medical Center Torrance California USAFielding School of Public Health UCLA Los Angeles California USAProteus Digital Health Redwood City California USAProteus Digital Health Redwood City California USALos Angeles Biomedical Research Institute at Harbor‐University of California Los Angeles (UCLA) Medical Center Torrance California USAUniversity of Nebraska Medical Center Omaha Nebraska USASchool of Dentistry University of California, Los Angeles (UCLA) Los Angeles California USAAdherence with antiretroviral therapy is important for preventing disease progression and HIV transmission. The co‐encapsulated pill sensor system sends a signal through a cutaneous patch and allows real‐time monitoring of pill ingestion. A 16‐week pilot study used a sensor system in 15 HIV‐infected individuals with real‐time monitoring of pill‐taking with a personalized short message system text. System acceptability was assessed by survey at weeks 4, 8, 12, and 16. Follow‐up occurred in 80% of subjects through 8 weeks. The system effectively collected measures of pill ingestion, which triggered text message reminders. Only 2 of 14 participants stated that co‐encapsulated pills were “unable to take” or “poorly tolerated.” At least 75% of respondents stated at each visit that the patch was very or somewhat comfortable. With regard to text message reminders, only 10–15% of the participants at any visit did not find the messages to be helpful. Larger studies will define the utility of this system to assess antiretroviral adherence relative to standard measures.https://doi.org/10.1111/cts.12701 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eric S. Daar Marc I. Rosen Yan Wang Lisa Siqueiros Jie Shen Mario Guerrero Di Xiong John Dao Todd Young Katya Corado Courtney V. Fletcher Honghu Liu |
spellingShingle |
Eric S. Daar Marc I. Rosen Yan Wang Lisa Siqueiros Jie Shen Mario Guerrero Di Xiong John Dao Todd Young Katya Corado Courtney V. Fletcher Honghu Liu Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study Clinical and Translational Science |
author_facet |
Eric S. Daar Marc I. Rosen Yan Wang Lisa Siqueiros Jie Shen Mario Guerrero Di Xiong John Dao Todd Young Katya Corado Courtney V. Fletcher Honghu Liu |
author_sort |
Eric S. Daar |
title |
Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study |
title_short |
Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study |
title_full |
Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study |
title_fullStr |
Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study |
title_full_unstemmed |
Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study |
title_sort |
real‐time and wireless assessment of adherence to antiretroviral therapy with co‐encapsulated ingestion sensor in hiv‐infected patients: a pilot study |
publisher |
Wiley |
series |
Clinical and Translational Science |
issn |
1752-8054 1752-8062 |
publishDate |
2020-01-01 |
description |
Adherence with antiretroviral therapy is important for preventing disease progression and HIV transmission. The co‐encapsulated pill sensor system sends a signal through a cutaneous patch and allows real‐time monitoring of pill ingestion. A 16‐week pilot study used a sensor system in 15 HIV‐infected individuals with real‐time monitoring of pill‐taking with a personalized short message system text. System acceptability was assessed by survey at weeks 4, 8, 12, and 16. Follow‐up occurred in 80% of subjects through 8 weeks. The system effectively collected measures of pill ingestion, which triggered text message reminders. Only 2 of 14 participants stated that co‐encapsulated pills were “unable to take” or “poorly tolerated.” At least 75% of respondents stated at each visit that the patch was very or somewhat comfortable. With regard to text message reminders, only 10–15% of the participants at any visit did not find the messages to be helpful. Larger studies will define the utility of this system to assess antiretroviral adherence relative to standard measures. |
url |
https://doi.org/10.1111/cts.12701 |
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