Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti
Background: Thymol and carvacrol have previously demonstrated larvicidal activity against Aedes aegypti (Diptera: Culicidae). In view of this fact, it was of our interest to obtain synthetic derivatives and evaluate their larvicidal activity on Ae. aegypti larvae. Methods: Structural modifications...
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doaj-f74c01152da84700985e53aab24d22f82020-11-25T02:11:37ZengTehran University of Medical SciencesJournal of Arthropod-Borne Diseases 1735-71792322-22712017-06-01112343Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegyptiViviane Barros Silva0Daniele Lima Travassos1Angelita Nepel2Andersson Barison3Emmanoel Vilaça Costa4Luciana Scotti5Marcus Tulius Scotti6rancisco Jaime Bezerra Mendonça-Junior7Roseli La Corte dos Santos8Sócrates Cabral de Holanda Cavalcanti9Medicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, BrazilMedicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, BrazilNuclear Magnetic Resonance Laboratory, Chemistry Department, Federal University of Paraná, Curitiba, BrazilNuclear Magnetic Resonance Laboratory, Chemistry Department, Federal University of Paraná, Curitiba, BrazilChemistry Department, Institute of Sciences, Federal University of Amazonas, Manaus, BrazilBiotechnology Center, Federal University of Paraíba, Campus I, João Pessoa, BrazilBiotechnology Center, Federal University of Paraíba, Campus I, João Pessoa, BrazilLaboratory of Synthesis and Delivery of Molecules, Biological Sciences Department, State University of Paraíba, João Pessoa, Paraiba, BrazilParasitology and Tropical Entomology Laboratory, Morphology Department, Federal University of Sergipe, São Cristóvão, BrazilMedicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, Brazil Background: Thymol and carvacrol have previously demonstrated larvicidal activity against Aedes aegypti (Diptera: Culicidae). In view of this fact, it was of our interest to obtain synthetic derivatives and evaluate their larvicidal activity on Ae. aegypti larvae. Methods: Structural modifications were performed on thymol and carvacrol in an effort to understand the functional groups necessary for modulating their activities and to lead possibly to more effective larvae control agents. The derivatives were further subjected to SAR and computational studies (molecular modeling and chemometric tools (CPCA and PCA)) to extract structural information regarding their larvicidal properties. Field collected and Rockefeller populations of Ae. aegypti were used. Results: Carvacrol and thymol exhibited LC50 of 51 and 58ppm for field collected larvae, respectively. Carvacrol derivatives exhibited LC50 ranging from 39 to 169ppm, while thymol derivatives exhibited LC50 ranging from 18 to 465ppm. Substitution of the acidic proton of carvacrol by esters, ethers, and acetic acid resulted in either maintenance or reduction of potency. Conclusion: Thymol derivatives were, to a certain extent, more efficient larvicides against Ae. aegypti than carvacrol derivatives, particularly to Rockefeller larvae. The chemometrics tools applied in this study showed that the independent variables indicate a mixed profile. Nevertheless, hydrophobic interactions increased the larvicidal activity. https://jad.tums.ac.ir/index.php/jad/article/view/598ChemometrySARDengueThymol derivativesCarvacrol derivatives |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Viviane Barros Silva Daniele Lima Travassos Angelita Nepel Andersson Barison Emmanoel Vilaça Costa Luciana Scotti Marcus Tulius Scotti rancisco Jaime Bezerra Mendonça-Junior Roseli La Corte dos Santos Sócrates Cabral de Holanda Cavalcanti |
spellingShingle |
Viviane Barros Silva Daniele Lima Travassos Angelita Nepel Andersson Barison Emmanoel Vilaça Costa Luciana Scotti Marcus Tulius Scotti rancisco Jaime Bezerra Mendonça-Junior Roseli La Corte dos Santos Sócrates Cabral de Holanda Cavalcanti Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti Journal of Arthropod-Borne Diseases Chemometry SAR Dengue Thymol derivatives Carvacrol derivatives |
author_facet |
Viviane Barros Silva Daniele Lima Travassos Angelita Nepel Andersson Barison Emmanoel Vilaça Costa Luciana Scotti Marcus Tulius Scotti rancisco Jaime Bezerra Mendonça-Junior Roseli La Corte dos Santos Sócrates Cabral de Holanda Cavalcanti |
author_sort |
Viviane Barros Silva |
title |
Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti |
title_short |
Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti |
title_full |
Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti |
title_fullStr |
Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti |
title_full_unstemmed |
Synthesis and Chemometrics of Thymol and Carvacrol Derivatives as Larvicides against Aedes aegypti |
title_sort |
synthesis and chemometrics of thymol and carvacrol derivatives as larvicides against aedes aegypti |
publisher |
Tehran University of Medical Sciences |
series |
Journal of Arthropod-Borne Diseases |
issn |
1735-7179 2322-2271 |
publishDate |
2017-06-01 |
description |
Background: Thymol and carvacrol have previously demonstrated larvicidal activity against Aedes aegypti (Diptera: Culicidae). In view of this fact, it was of our interest to obtain synthetic derivatives and evaluate their larvicidal activity on Ae. aegypti larvae.
Methods: Structural modifications were performed on thymol and carvacrol in an effort to understand the functional groups necessary for modulating their activities and to lead possibly to more effective larvae control agents. The derivatives were further subjected to SAR and computational studies (molecular modeling and chemometric tools (CPCA and PCA)) to extract structural information regarding their larvicidal properties. Field collected and Rockefeller populations of Ae. aegypti were used.
Results: Carvacrol and thymol exhibited LC50 of 51 and 58ppm for field collected larvae, respectively. Carvacrol derivatives exhibited LC50 ranging from 39 to 169ppm, while thymol derivatives exhibited LC50 ranging from 18 to 465ppm. Substitution of the acidic proton of carvacrol by esters, ethers, and acetic acid resulted in either maintenance or reduction of potency.
Conclusion: Thymol derivatives were, to a certain extent, more efficient larvicides against Ae. aegypti than carvacrol derivatives, particularly to Rockefeller larvae. The chemometrics tools applied in this study showed that the independent variables indicate a mixed profile. Nevertheless, hydrophobic interactions increased the larvicidal activity.
|
topic |
Chemometry SAR Dengue Thymol derivatives Carvacrol derivatives |
url |
https://jad.tums.ac.ir/index.php/jad/article/view/598 |
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