In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1

In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1

The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective to PGHS-1/PGHS-2 and time dependent/independent...

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Bibliographic Details
Main Authors: Alexey Goltsov, Galina Lebedeva, Ian Humphery-Smith, Gregory Goltsov, Oleg Demin, Igor Goryanin
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Pharmaceuticals
Subjects:
kinetic modeling
COX-1,2
NSAID
aspirin resistance
NSAID combination
Online Access:http://www.mdpi.com/1424-8247/3/7/2059/

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