The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism
With the improvement of living conditions and the popularity of unhealthy eating and living habits, obesity is becoming a global epidemic. Obesity is now recognized as a disease that not only increases the risk of metabolic diseases such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (N...
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2021-06-01
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doaj-f76570b185d246479608923289e724312021-06-21T08:00:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-06-011210.3389/fphar.2021.696603696603The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid MetabolismQijing Fan0Furong Xu1Bin Liang2Xiaoju Zou3College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming, ChinaCollege of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming, ChinaCenter for Life Sciences, School of Life Sciences, Yunnan University, Kunming, ChinaCollege of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming, ChinaWith the improvement of living conditions and the popularity of unhealthy eating and living habits, obesity is becoming a global epidemic. Obesity is now recognized as a disease that not only increases the risk of metabolic diseases such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and cancer but also negatively affects longevity and the quality of life. The traditional Chinese medicines (TCMs) are highly enriched in bioactive compounds and have been used for the treatment of obesity and obesity-related metabolic diseases over a long period of time. In this review, we selected the most commonly used anti-obesity or anti-hyperlipidemia TCMs and, where known, their major bioactive compounds. We then summarized their multi-target molecular mechanisms, specifically focusing on lipid metabolism, including the modulation of lipid absorption, reduction of lipid synthesis, and increase of lipid decomposition and lipid transportation, as well as the regulation of appetite. This review produces a current and comprehensive understanding of integrative and systematic mechanisms for the use of TCMs for anti-obesity. We also advocate taking advantage of TCMs as another therapy for interventions on obesity-related diseases, as well as stressing the fact that more is needed to be done, scientifically, to determine the active compounds and modes of action of the TCMs.https://www.frontiersin.org/articles/10.3389/fphar.2021.696603/fulltraditional Chinese medicinesobesity-related metabolic diseasesanti-obesity effectlipid metabolismmechanisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qijing Fan Furong Xu Bin Liang Xiaoju Zou |
spellingShingle |
Qijing Fan Furong Xu Bin Liang Xiaoju Zou The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism Frontiers in Pharmacology traditional Chinese medicines obesity-related metabolic diseases anti-obesity effect lipid metabolism mechanisms |
author_facet |
Qijing Fan Furong Xu Bin Liang Xiaoju Zou |
author_sort |
Qijing Fan |
title |
The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism |
title_short |
The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism |
title_full |
The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism |
title_fullStr |
The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism |
title_full_unstemmed |
The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism |
title_sort |
anti-obesity effect of traditional chinese medicine on lipid metabolism |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2021-06-01 |
description |
With the improvement of living conditions and the popularity of unhealthy eating and living habits, obesity is becoming a global epidemic. Obesity is now recognized as a disease that not only increases the risk of metabolic diseases such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and cancer but also negatively affects longevity and the quality of life. The traditional Chinese medicines (TCMs) are highly enriched in bioactive compounds and have been used for the treatment of obesity and obesity-related metabolic diseases over a long period of time. In this review, we selected the most commonly used anti-obesity or anti-hyperlipidemia TCMs and, where known, their major bioactive compounds. We then summarized their multi-target molecular mechanisms, specifically focusing on lipid metabolism, including the modulation of lipid absorption, reduction of lipid synthesis, and increase of lipid decomposition and lipid transportation, as well as the regulation of appetite. This review produces a current and comprehensive understanding of integrative and systematic mechanisms for the use of TCMs for anti-obesity. We also advocate taking advantage of TCMs as another therapy for interventions on obesity-related diseases, as well as stressing the fact that more is needed to be done, scientifically, to determine the active compounds and modes of action of the TCMs. |
topic |
traditional Chinese medicines obesity-related metabolic diseases anti-obesity effect lipid metabolism mechanisms |
url |
https://www.frontiersin.org/articles/10.3389/fphar.2021.696603/full |
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