STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD
The search for new compounds with а high nootropic biological activity is a promising scientific direction. A modern computational method for predicting pharmacological activity of the studied compounds is the molecular docking. The aim of this work is to study the affinity of new N-acyl derivatives...
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doaj-f76ad5ab89dd4725a5562d22dc29e9bb2021-09-02T13:56:03ZengScientia Publishing HouseJuvenis Scientia2414-37822414-37902019-03-0134610.32415/jscientia.2019.03.01STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHODChiriapkin A.S.0Glushko A.A.1Kodonidi I.P.2Volgograd Medical State UniversityVolgograd Medical State UniversityVolgograd Medical State UniversityThe search for new compounds with а high nootropic biological activity is a promising scientific direction. A modern computational method for predicting pharmacological activity of the studied compounds is the molecular docking. The aim of this work is to study the affinity of new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide to the binding site of NMDA receptor to search of new effective nootropic drugs. As objects of study, there are used the new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide, racetams, glutamate and a virtual model of NMDA receptor of organism Rattus norvegicus with an identification code 2A5S from the RCSB PDB database. The results of the computational experiment indicate the presence of high nootropic biological activity in the compounds under study. Substance 3 has the greatest affinity of the N-acyl derivatives of 2-oxo-1-pyrrolidineethanol to the binding site of NMDA receptor Thus, we consider it is appropriate to conduct pharmacological in vivo studies of these compounds for the presence of nootropic biological activity.2-oxo-1-pyrrolidine acetamideN-acyl derivativesNMDA receptormolecular dockingbinding sitebiological activitypredict.predict |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chiriapkin A.S. Glushko A.A. Kodonidi I.P. |
spellingShingle |
Chiriapkin A.S. Glushko A.A. Kodonidi I.P. STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD Juvenis Scientia 2-oxo-1-pyrrolidine acetamide N-acyl derivatives NMDA receptor molecular docking binding site biological activity predict. predict |
author_facet |
Chiriapkin A.S. Glushko A.A. Kodonidi I.P. |
author_sort |
Chiriapkin A.S. |
title |
STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD |
title_short |
STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD |
title_full |
STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD |
title_fullStr |
STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD |
title_full_unstemmed |
STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD |
title_sort |
study of the affinity of n-acyl derivatives of 2-oxo-1-pyrrolidine acetamide to the binding site of nmda receptor by molecular docking method |
publisher |
Scientia Publishing House |
series |
Juvenis Scientia |
issn |
2414-3782 2414-3790 |
publishDate |
2019-03-01 |
description |
The search for new compounds with а high nootropic biological activity is a promising scientific direction. A modern computational method for predicting pharmacological activity of the studied compounds is the molecular docking. The aim of this work is to study the affinity of new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide to the binding site of NMDA receptor to search of new effective nootropic drugs. As objects of study, there are used the new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide, racetams, glutamate and a virtual model of NMDA receptor of organism Rattus norvegicus with an identification code 2A5S from the RCSB PDB database. The results of the computational experiment indicate the presence of high nootropic biological activity in the compounds under study. Substance 3 has the greatest affinity of the N-acyl derivatives of 2-oxo-1-pyrrolidineethanol to the binding site of NMDA receptor Thus, we consider it is appropriate to conduct pharmacological in vivo studies of these compounds for the presence of nootropic biological activity. |
topic |
2-oxo-1-pyrrolidine acetamide N-acyl derivatives NMDA receptor molecular docking binding site biological activity predict. predict |
work_keys_str_mv |
AT chiriapkinas studyoftheaffinityofnacylderivativesof2oxo1pyrrolidineacetamidetothebindingsiteofnmdareceptorbymoleculardockingmethod AT glushkoaa studyoftheaffinityofnacylderivativesof2oxo1pyrrolidineacetamidetothebindingsiteofnmdareceptorbymoleculardockingmethod AT kodonidiip studyoftheaffinityofnacylderivativesof2oxo1pyrrolidineacetamidetothebindingsiteofnmdareceptorbymoleculardockingmethod |
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1721174739334987776 |