Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with the...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07863-x |
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doaj-f76d0c11b2064d1e81bbe40dde812983 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Simon Haworth Chin Yang Shapland Caroline Hayward Bram P. Prins Janine F. Felix Carolina Medina-Gomez Fernando Rivadeneira Carol Wang Tarunveer S. Ahluwalia Martine Vrijheid Mònica Guxens Jordi Sunyer Ioanna Tachmazidou Klaudia Walter Valentina Iotchkova Andrew Jackson Louise Cleal Jennifer Huffmann Josine L. Min Lærke Sass Paul R. H. J. Timmers UK10K consortium George Davey Smith Simon E. Fisher James F. Wilson Tim J. Cole Dietmar Fernandez-Orth Klaus Bønnelykke Hans Bisgaard Craig E. Pennell Vincent W. V. Jaddoe George Dedoussis Nicholas Timpson Eleftheria Zeggini Veronique Vitart Beate St Pourcain |
| spellingShingle |
Simon Haworth Chin Yang Shapland Caroline Hayward Bram P. Prins Janine F. Felix Carolina Medina-Gomez Fernando Rivadeneira Carol Wang Tarunveer S. Ahluwalia Martine Vrijheid Mònica Guxens Jordi Sunyer Ioanna Tachmazidou Klaudia Walter Valentina Iotchkova Andrew Jackson Louise Cleal Jennifer Huffmann Josine L. Min Lærke Sass Paul R. H. J. Timmers UK10K consortium George Davey Smith Simon E. Fisher James F. Wilson Tim J. Cole Dietmar Fernandez-Orth Klaus Bønnelykke Hans Bisgaard Craig E. Pennell Vincent W. V. Jaddoe George Dedoussis Nicholas Timpson Eleftheria Zeggini Veronique Vitart Beate St Pourcain Low-frequency variation in TP53 has large effects on head circumference and intracranial volume Nature Communications |
| author_facet |
Simon Haworth Chin Yang Shapland Caroline Hayward Bram P. Prins Janine F. Felix Carolina Medina-Gomez Fernando Rivadeneira Carol Wang Tarunveer S. Ahluwalia Martine Vrijheid Mònica Guxens Jordi Sunyer Ioanna Tachmazidou Klaudia Walter Valentina Iotchkova Andrew Jackson Louise Cleal Jennifer Huffmann Josine L. Min Lærke Sass Paul R. H. J. Timmers UK10K consortium George Davey Smith Simon E. Fisher James F. Wilson Tim J. Cole Dietmar Fernandez-Orth Klaus Bønnelykke Hans Bisgaard Craig E. Pennell Vincent W. V. Jaddoe George Dedoussis Nicholas Timpson Eleftheria Zeggini Veronique Vitart Beate St Pourcain |
| author_sort |
Simon Haworth |
| title |
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume |
| title_short |
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume |
| title_full |
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume |
| title_fullStr |
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume |
| title_full_unstemmed |
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume |
| title_sort |
low-frequency variation in tp53 has large effects on head circumference and intracranial volume |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-01-01 |
| description |
Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits. |
| url |
https://doi.org/10.1038/s41467-018-07863-x |
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doaj-f76d0c11b2064d1e81bbe40dde8129832021-05-11T11:59:13ZengNature Publishing GroupNature Communications2041-17232019-01-0110111610.1038/s41467-018-07863-xLow-frequency variation in TP53 has large effects on head circumference and intracranial volumeSimon Haworth0Chin Yang Shapland1Caroline Hayward2Bram P. Prins3Janine F. Felix4Carolina Medina-Gomez5Fernando Rivadeneira6Carol Wang7Tarunveer S. Ahluwalia8Martine Vrijheid9Mònica Guxens10Jordi Sunyer11Ioanna Tachmazidou12Klaudia Walter13Valentina Iotchkova14Andrew Jackson15Louise Cleal16Jennifer Huffmann17Josine L. Min18Lærke Sass19Paul R. H. J. Timmers20UK10K consortiumGeorge Davey Smith21Simon E. Fisher22James F. Wilson23Tim J. Cole24Dietmar Fernandez-Orth25Klaus Bønnelykke26Hans Bisgaard27Craig E. Pennell28Vincent W. V. Jaddoe29George Dedoussis30Nicholas Timpson31Eleftheria Zeggini32Veronique Vitart33Beate St Pourcain34MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of BristolLanguage and Genetics Department, Max Planck Institute for PsycholinguisticsMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of EdinburghWellcome Sanger Institute, Wellcome Genome CampusThe Generation R Study Group, Erasmus MC, University Medical Center RotterdamThe Generation R Study Group, Erasmus MC, University Medical Center RotterdamThe Generation R Study Group, Erasmus MC, University Medical Center RotterdamSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of NewcastleCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of CopenhagenISGlobalISGlobalISGlobalWellcome Sanger Institute, Wellcome Genome CampusWellcome Sanger Institute, Wellcome Genome CampusWellcome Sanger Institute, Wellcome Genome CampusMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of EdinburghMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of EdinburghMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of EdinburghMRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of BristolCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of CopenhagenCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of EdinburghMRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of BristolLanguage and Genetics Department, Max Planck Institute for PsycholinguisticsMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of EdinburghFaculty of Population Health Sciences, UCL Great Ormond Street Institute of Child HealthISGlobalCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of CopenhagenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of CopenhagenSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of NewcastleThe Generation R Study Group, Erasmus MC, University Medical Center RotterdamDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio UniversityMRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of BristolWellcome Sanger Institute, Wellcome Genome CampusMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of EdinburghMRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of BristolSize and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.https://doi.org/10.1038/s41467-018-07863-x |