An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease
Inflammatory bowel disease, consisting of Crohn’s disease and ulcerative colitis, causes chronic gastrointestinal symptoms and can lead to morbidity and mortality if uncontrolled or untreated. However, for patients with moderate-to-severe disease, currently available therapies do not induce or maint...
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European Medical Journal
2020-12-01
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doaj-f76fe834e0164a2eaaf2c60565296fea2020-12-16T10:24:26ZengEuropean Medical JournalEuropean Medical Journal Gastroenterology2054-62032020-12-019191101An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease Sumona Bhattacharya0Raymond K. Cross1Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USAUniversity of Maryland School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Baltimore, Maryland, USAInflammatory bowel disease, consisting of Crohn’s disease and ulcerative colitis, causes chronic gastrointestinal symptoms and can lead to morbidity and mortality if uncontrolled or untreated. However, for patients with moderate-to-severe disease, currently available therapies do not induce or maintain remission in >50% of patients. This underscores the need for additional therapies. In this review, the authors detail the novel therapies vedolizumab, tofacitinib, and ustekinumab and delve into therapies which may come onto the market within the next 10 years, including JAK-1 inhibitors (filgotinib and upadacitinib), IL-23 inhibitors (guselkumab, mirikizumab, and risankizumab), the anti-β4β7 and anti-βEβ7 integrin monoclonal antibody etrolizumab, the sphingosine-1-phosphate subtypes 1 and 5 modulator ozanimod, and mesenchymal stem cells. Further studies are required before these emerging therapies gain approval.https://www.emjreviews.com/gastroenterology/article/an-overview-of-novel-and-emerging-therapies-for-inflammatory-bowel-disease/biologic therapycrohn's disease (cd)inflammatory bowel disease (ibd)jak inhibitionulcerative colitis (uc) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sumona Bhattacharya Raymond K. Cross |
spellingShingle |
Sumona Bhattacharya Raymond K. Cross An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease European Medical Journal Gastroenterology biologic therapy crohn's disease (cd) inflammatory bowel disease (ibd) jak inhibition ulcerative colitis (uc) |
author_facet |
Sumona Bhattacharya Raymond K. Cross |
author_sort |
Sumona Bhattacharya |
title |
An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease |
title_short |
An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease |
title_full |
An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease |
title_fullStr |
An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease |
title_full_unstemmed |
An Overview of Novel and Emerging Therapies for Inflammatory Bowel Disease |
title_sort |
overview of novel and emerging therapies for inflammatory bowel disease |
publisher |
European Medical Journal |
series |
European Medical Journal Gastroenterology |
issn |
2054-6203 |
publishDate |
2020-12-01 |
description |
Inflammatory bowel disease, consisting of Crohn’s disease and ulcerative colitis, causes chronic gastrointestinal symptoms and can lead to morbidity and mortality if uncontrolled or untreated. However, for patients with moderate-to-severe disease, currently available therapies do not induce or maintain remission in >50% of patients. This underscores the need for additional therapies. In this review, the authors detail the novel therapies vedolizumab, tofacitinib, and ustekinumab and delve into therapies which may come onto the market within the next 10 years, including JAK-1 inhibitors (filgotinib and upadacitinib), IL-23 inhibitors (guselkumab, mirikizumab, and risankizumab), the anti-β4β7 and anti-βEβ7 integrin monoclonal antibody etrolizumab, the sphingosine-1-phosphate subtypes 1 and 5 modulator ozanimod, and mesenchymal stem cells. Further studies are required before these emerging therapies gain approval. |
topic |
biologic therapy crohn's disease (cd) inflammatory bowel disease (ibd) jak inhibition ulcerative colitis (uc) |
url |
https://www.emjreviews.com/gastroenterology/article/an-overview-of-novel-and-emerging-therapies-for-inflammatory-bowel-disease/ |
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