Advances of oligodendrocytes and myelination involving in learning and memory

• Main Authors: YAO Zhongxiang, HU Bo
• Format: Article
• Language: zho
• Published: Editorial Office of Journal of Third Military Medical University 2020-05-01
• Series: Di-san junyi daxue xuebao
• Subjects: oligodendrocyte; myelination; learning and memory; alzheimer's disease; pharmacotherapy; cognitive impairment
• Online Access: http://aammt.tmmu.edu.cn/Upload/rhtml/202002018.htm

Neuronal activity and learning can regulate the adult oligodendrogenesis. However, functional significance of this regulation remains not fully clear. Here, we reviewed the most recent progresses in the field of oligodendrocytes and myelination involved in learning and memory. Firstly, we introduce the evidence demonstrating that the oligodendrocytes and myelination are involved in learning and memory. Secondly, we show the gene expression changes of oligodendrocytes, which are closely associated with the progression of Alzheimer's disease. Third, we introduce a few of drug administration which are used to promote oligodendroglial differentiation and myelination and to rescue impairment of learning and memory. At last, we analyze the shortage of current research and propose the trend for future researches.