Emicrania mestruale: esperienza con ossicodone/naloxone a rilascio prolungato - Menstrual migraine: experience with oxicodone/naloxone extended release
Menstrual migraine represent a big challenge for practitioners. Various therapy try to alleviate these attacks, usually long half-life triptans and-or anti-inflammatory drugs, combined with caffeine, magnesium etc, but sometimes without efficacy. To support this limited class of patients, we conside...
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| Format: | Article |
| Language: | English |
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Publiediting
2016-03-01
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| Series: | Pathos |
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| Online Access: | https://www.pathos-journal.com/2016_1_162.html |
| Summary: | Menstrual migraine represent a big challenge for practitioners. Various therapy try to alleviate these attacks, usually long half-life triptans and-or anti-inflammatory drugs, combined with caffeine, magnesium etc, but sometimes without efficacy. To support this limited class of patients, we considered to use the Oxycodone/Naloxone Extended Release (O/N-ER) for its favourable mechanism of action on neuropathic pain, long half life and well documented gastrointestinal safety. Recruitment is only for patients non-responders to classical preventive therapy. We have collected 33 patients, 25 with pure menstrual migraine, 8 with menstrual correlated migraine, reduction of days with migraine was significant passing from 3,5 to 2 day per attack,with also a significant reduction in pain at NRS scale from 7,7 with classical preventive therapy to 4,1 with O/N-ER, with also high level of tollerability. |
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| ISSN: | 1593-2354 2385-0744 |