The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells
Mesenchymal (stem) stromal cells (MSC) can be a therapeutic alternative for COVID-19 considering their anti-inflammatory, regenerative, angiogenic, and even antimicrobial capacity. Preliminary data point to therapeutic interest of MSC for patients with COVID-19, and their effect seems based on the M...
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doaj-f7776f265ffd42e1bf0246654f58f1e02020-11-25T02:54:40ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-07-01810.3389/fcell.2020.00645556558The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal CellsNoemi Eiro0Noemi Eiro1Jorge Ruben Cabrera2Jorge Ruben Cabrera3Maria Fraile4Maria Fraile5Luis Costa6Luis Costa7Francisco J. Vizoso8Francisco J. Vizoso9Research Unit, Fundación Hospital de Jove, Gijón, SpainFoundation for Research With Uterine Stem Cells - FICEMU, Gijón, SpainResearch Unit, Fundación Hospital de Jove, Gijón, SpainFoundation for Research With Uterine Stem Cells - FICEMU, Gijón, SpainResearch Unit, Fundación Hospital de Jove, Gijón, SpainFoundation for Research With Uterine Stem Cells - FICEMU, Gijón, SpainResearch Unit, Fundación Hospital de Jove, Gijón, SpainFoundation for Research With Uterine Stem Cells - FICEMU, Gijón, SpainResearch Unit, Fundación Hospital de Jove, Gijón, SpainFoundation for Research With Uterine Stem Cells - FICEMU, Gijón, SpainMesenchymal (stem) stromal cells (MSC) can be a therapeutic alternative for COVID-19 considering their anti-inflammatory, regenerative, angiogenic, and even antimicrobial capacity. Preliminary data point to therapeutic interest of MSC for patients with COVID-19, and their effect seems based on the MSC’s ability to curb the cytokine storm caused by COVID-19. In fact, promising clinical studies using MSC to treat COVID-19, are currently underway. For this reason, now is the time to firmly consider new approaches to MSC research that addresses key issues, like selecting the most optimal type of MSC for each indication, assuming the heterogeneity of the donor-dependent MSC and the biological niche where MSC are located.https://www.frontiersin.org/article/10.3389/fcell.2020.00645/fullCOVID-19SARS-CoV-2mesenchymal stromal cellextracellular vesiclesexosomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Noemi Eiro Noemi Eiro Jorge Ruben Cabrera Jorge Ruben Cabrera Maria Fraile Maria Fraile Luis Costa Luis Costa Francisco J. Vizoso Francisco J. Vizoso |
spellingShingle |
Noemi Eiro Noemi Eiro Jorge Ruben Cabrera Jorge Ruben Cabrera Maria Fraile Maria Fraile Luis Costa Luis Costa Francisco J. Vizoso Francisco J. Vizoso The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells Frontiers in Cell and Developmental Biology COVID-19 SARS-CoV-2 mesenchymal stromal cell extracellular vesicles exosomes |
author_facet |
Noemi Eiro Noemi Eiro Jorge Ruben Cabrera Jorge Ruben Cabrera Maria Fraile Maria Fraile Luis Costa Luis Costa Francisco J. Vizoso Francisco J. Vizoso |
author_sort |
Noemi Eiro |
title |
The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells |
title_short |
The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells |
title_full |
The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells |
title_fullStr |
The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells |
title_full_unstemmed |
The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells |
title_sort |
coronavirus pandemic (sars-cov-2): new problems demand new solutions, the alternative of mesenchymal (stem) stromal cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-07-01 |
description |
Mesenchymal (stem) stromal cells (MSC) can be a therapeutic alternative for COVID-19 considering their anti-inflammatory, regenerative, angiogenic, and even antimicrobial capacity. Preliminary data point to therapeutic interest of MSC for patients with COVID-19, and their effect seems based on the MSC’s ability to curb the cytokine storm caused by COVID-19. In fact, promising clinical studies using MSC to treat COVID-19, are currently underway. For this reason, now is the time to firmly consider new approaches to MSC research that addresses key issues, like selecting the most optimal type of MSC for each indication, assuming the heterogeneity of the donor-dependent MSC and the biological niche where MSC are located. |
topic |
COVID-19 SARS-CoV-2 mesenchymal stromal cell extracellular vesicles exosomes |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00645/full |
work_keys_str_mv |
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