Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C
Understanding neurodegenerative disease progression and its treatment requires the systematic characterization and manipulation of relevant cell types and molecular pathways. The neurodegenerative lysosomal storage disorder Niemann-Pick disease type C (NPC) is highly amenable to genetic approaches t...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2013-09-01
|
Series: | Disease Models & Mechanisms |
Online Access: | http://dmm.biologists.org/content/6/5/1089 |