Factors associated with mumps meningitis and the possible impact of vaccination
PurposeMumps meningitis is a common complication of mumps infection; however, information on mumps meningitis in the postvaccine era is limited. The purpose of the present study was to determine factors associated with mumps meningitis and to discuss the effect of vaccination on this disease.Methods...
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doaj-f77a8ddeeb9248da81427785c568cc7b2020-11-25T00:03:10ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582016-01-01591242910.3345/kjp.2016.59.1.2420125550509Factors associated with mumps meningitis and the possible impact of vaccinationKyuyol Rhie0Heung-Keun Park1Young-Soo Kim2Jung Sook Yeom3Ji Sook Park4Ji-Hyun Seo5Eun Sil Park6Jae-Young Lim7Chan-Hoo Park8Hyang-Ok Woo9Hee-Shang Youn10Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea.PurposeMumps meningitis is a common complication of mumps infection; however, information on mumps meningitis in the postvaccine era is limited. The purpose of the present study was to determine factors associated with mumps meningitis and to discuss the effect of vaccination on this disease.MethodsWe retrospectively reviewed patients younger than 19 years with mumps, diagnosed at a university hospital in Korea between 2003 and 2013. Patients were divided into groups with and without meningitis, and the clinical features of the 2 groups were compared.ResultsThe study enrolled 119 patients: 19 patients with meningitis and 100 patients without. Univariate analysis showed that older age (median: 15 years vs. 9.5 years, respectively), a longer interval from last vaccination (median: 10.2 years vs. 4.8 years, respectively), and febrile presentation (94.7% vs. 31.0%, respectively) were significantly associated with mumps meningitis. Sex, number of vaccination doses, bilateral parotitis, and the presence of complications other than meningitis did not differ between the 2 groups. In multivariate logistic regression analysis, age (odds ratio, 1.38; 95% confidence interval, 1.01–1.89; P=0.04) and fever (odds ratio, 30.46; 95% confidence interval, 3.27–283.61; P<0.01) remained independent factors for mumps meningitis.ConclusionClinicians in the postvaccine era should be aware of the possibility of mumps meningitis in febrile cases of mumps in adolescents, regardless of the number of vaccination doses. To establish the role of vaccination in mumps meningitis, further studies will be necessary.http://kjp.or.kr/upload/pdf/kjped-59-24.pdfMumpsViral meningitisMeasles-mumps-rubella vaccineChild |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyuyol Rhie Heung-Keun Park Young-Soo Kim Jung Sook Yeom Ji Sook Park Ji-Hyun Seo Eun Sil Park Jae-Young Lim Chan-Hoo Park Hyang-Ok Woo Hee-Shang Youn |
spellingShingle |
Kyuyol Rhie Heung-Keun Park Young-Soo Kim Jung Sook Yeom Ji Sook Park Ji-Hyun Seo Eun Sil Park Jae-Young Lim Chan-Hoo Park Hyang-Ok Woo Hee-Shang Youn Factors associated with mumps meningitis and the possible impact of vaccination Korean Journal of Pediatrics Mumps Viral meningitis Measles-mumps-rubella vaccine Child |
author_facet |
Kyuyol Rhie Heung-Keun Park Young-Soo Kim Jung Sook Yeom Ji Sook Park Ji-Hyun Seo Eun Sil Park Jae-Young Lim Chan-Hoo Park Hyang-Ok Woo Hee-Shang Youn |
author_sort |
Kyuyol Rhie |
title |
Factors associated with mumps meningitis and the possible impact of vaccination |
title_short |
Factors associated with mumps meningitis and the possible impact of vaccination |
title_full |
Factors associated with mumps meningitis and the possible impact of vaccination |
title_fullStr |
Factors associated with mumps meningitis and the possible impact of vaccination |
title_full_unstemmed |
Factors associated with mumps meningitis and the possible impact of vaccination |
title_sort |
factors associated with mumps meningitis and the possible impact of vaccination |
publisher |
Korean Pediatric Society |
series |
Korean Journal of Pediatrics |
issn |
1738-1061 2092-7258 |
publishDate |
2016-01-01 |
description |
PurposeMumps meningitis is a common complication of mumps infection; however, information on mumps meningitis in the postvaccine era is limited. The purpose of the present study was to determine factors associated with mumps meningitis and to discuss the effect of vaccination on this disease.MethodsWe retrospectively reviewed patients younger than 19 years with mumps, diagnosed at a university hospital in Korea between 2003 and 2013. Patients were divided into groups with and without meningitis, and the clinical features of the 2 groups were compared.ResultsThe study enrolled 119 patients: 19 patients with meningitis and 100 patients without. Univariate analysis showed that older age (median: 15 years vs. 9.5 years, respectively), a longer interval from last vaccination (median: 10.2 years vs. 4.8 years, respectively), and febrile presentation (94.7% vs. 31.0%, respectively) were significantly associated with mumps meningitis. Sex, number of vaccination doses, bilateral parotitis, and the presence of complications other than meningitis did not differ between the 2 groups. In multivariate logistic regression analysis, age (odds ratio, 1.38; 95% confidence interval, 1.01–1.89; P=0.04) and fever (odds ratio, 30.46; 95% confidence interval, 3.27–283.61; P<0.01) remained independent factors for mumps meningitis.ConclusionClinicians in the postvaccine era should be aware of the possibility of mumps meningitis in febrile cases of mumps in adolescents, regardless of the number of vaccination doses. To establish the role of vaccination in mumps meningitis, further studies will be necessary. |
topic |
Mumps Viral meningitis Measles-mumps-rubella vaccine Child |
url |
http://kjp.or.kr/upload/pdf/kjped-59-24.pdf |
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