Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding

The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using comp...

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Main Authors: Neno Bratoev, Aneliya Milanova, Ivelina Pavlova, Lubomir Lashev
Format: Article
Language:English
Published: Ss.Cyril and Methodius University, Skopje 2016-10-01
Series:Macedonian Veterinary Review
Subjects:
Online Access:http://www.macvetrev.mk/2016-2/macvetrev-2016-0086.pdf
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spelling doaj-f782e90042de43ffb6348c76d4b1a67e2020-11-24T21:28:35ZengSs.Cyril and Methodius University, SkopjeMacedonian Veterinary Review 1409-76211857-74152016-10-0139221922410.1515/macvetrev-2016-0086 Pharmacokinetics of doxycycline in ducks with steatosis due to force-feedingNeno Bratoev0Aneliya Milanova1Ivelina Pavlova2Lubomir Lashev3Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaDepartment of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaDepartment of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaDepartment of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaThe pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.http://www.macvetrev.mk/2016-2/macvetrev-2016-0086.pdfdoxycyclineducksforce-feedingpharmacokinetics
collection DOAJ
language English
format Article
sources DOAJ
author Neno Bratoev
Aneliya Milanova
Ivelina Pavlova
Lubomir Lashev
spellingShingle Neno Bratoev
Aneliya Milanova
Ivelina Pavlova
Lubomir Lashev
Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
Macedonian Veterinary Review
doxycycline
ducks
force-feeding
pharmacokinetics
author_facet Neno Bratoev
Aneliya Milanova
Ivelina Pavlova
Lubomir Lashev
author_sort Neno Bratoev
title Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
title_short Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
title_full Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
title_fullStr Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
title_full_unstemmed Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
title_sort pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
publisher Ss.Cyril and Methodius University, Skopje
series Macedonian Veterinary Review
issn 1409-7621
1857-7415
publishDate 2016-10-01
description The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.
topic doxycycline
ducks
force-feeding
pharmacokinetics
url http://www.macvetrev.mk/2016-2/macvetrev-2016-0086.pdf
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