Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding
The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using comp...
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Ss.Cyril and Methodius University, Skopje
2016-10-01
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doaj-f782e90042de43ffb6348c76d4b1a67e2020-11-24T21:28:35ZengSs.Cyril and Methodius University, SkopjeMacedonian Veterinary Review 1409-76211857-74152016-10-0139221922410.1515/macvetrev-2016-0086 Pharmacokinetics of doxycycline in ducks with steatosis due to force-feedingNeno Bratoev0Aneliya Milanova1Ivelina Pavlova2Lubomir Lashev3Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaDepartment of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaDepartment of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaDepartment of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, BulgariaThe pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.http://www.macvetrev.mk/2016-2/macvetrev-2016-0086.pdfdoxycyclineducksforce-feedingpharmacokinetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neno Bratoev Aneliya Milanova Ivelina Pavlova Lubomir Lashev |
spellingShingle |
Neno Bratoev Aneliya Milanova Ivelina Pavlova Lubomir Lashev Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding Macedonian Veterinary Review doxycycline ducks force-feeding pharmacokinetics |
author_facet |
Neno Bratoev Aneliya Milanova Ivelina Pavlova Lubomir Lashev |
author_sort |
Neno Bratoev |
title |
Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding |
title_short |
Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding |
title_full |
Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding |
title_fullStr |
Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding |
title_full_unstemmed |
Pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding |
title_sort |
pharmacokinetics of doxycycline in ducks with steatosis due to force-feeding |
publisher |
Ss.Cyril and Methodius University, Skopje |
series |
Macedonian Veterinary Review |
issn |
1409-7621 1857-7415 |
publishDate |
2016-10-01 |
description |
The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones. |
topic |
doxycycline ducks force-feeding pharmacokinetics |
url |
http://www.macvetrev.mk/2016-2/macvetrev-2016-0086.pdf |
work_keys_str_mv |
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