Evaluation of serum MUC5AC in combination with CA19-9 for the diagnosis of pancreatic cancer

Evaluation of serum MUC5AC in combination with CA19-9 for the diagnosis of pancreatic cancer

Abstract Background Pancreatic cancer (PC) is a highly aggressive tumor with a poor prognosis that lacks specific diagnostic markers. Mucin 5AC (MUC5AC) is a member of the mucin family, a heterogeneous group of high molecular weight, heavily glycosylated proteins that could be either membrane-bound...

Full description

Bibliographic Details
Main Authors:	Jiayu Zhang, Yue Wang, Tiancheng Zhao, Yezhou Li, Leilei Tian, Jinming Zhao, Jingxin Zhang
Format:	Article
Language:	English
Published:	BMC 2020-02-01
Series:	World Journal of Surgical Oncology
Subjects:	Biomarker Carbohydrate antigen 19-9 (CA19-9) Mucin 5AC (MUC5AC) Pancreatic cancer (PC)
Online Access:	https://doi.org/10.1186/s12957-020-1809-z

Similar Items

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B
by: Luke R. Bonser, et al.
Published: (2017-11-01)

Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCα/ERK1-2 Pathway
by: Simona Damiano, et al.
Published: (2018-04-01)

Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas
by: Onur Oral, et al.
Published: (2020-01-01)

Overexpression of Substance P in pig airways increases MUC5AC through an NF‐kβ pathway
by: Mariana Sponchiado, et al.
Published: (2021-02-01)

The Effect of Long-Term Use of an Eyewash Solution on the Ocular Surface Mucin Layer
by: Hiroyuki Yazu, et al.
Published: (2019-10-01)

Telmisartan mitigates lipopolysaccharide (LPS)-induced production of mucin 5AC (MUC5AC) through increasing suppressor of cytokine signaling 1 (SOCS1)
by: Ling Chen, et al.
Published: (2021-01-01)

Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ
by: Takahito Oyanagi, et al.
Published: (2017-01-01)

Development of a highly sensitive and reliable enzyme-linked immunosorbent assay for MUC5AC in human tears extracted from Schirmer strips
by: Miyake H, et al.
Published: (2018-08-01)

Muc5ac mucin expression during rat skin development
by: V. Ferretti, et al.
Published: (2015-02-01)

Integrin β1 subunit regulates cellular and secreted MUC5AC and MUC5B production in NCI–H292 human lung epithelial cells
by: Jun Iwashita, et al.
Published: (2021-12-01)

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance
by: Ramesh Pothuraju, et al.
Published: (2020-02-01)

Impact of combined surgery on the MUC5AC levels in patients with glaucoma and cataract
by: Xue-Fei Wang, et al.
Published: (2015-01-01)

Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K/Akt/NF-kB in Asthma
by: Chen X, et al.
Published: (2021-08-01)

Carbocisteine inhibits the expression of Muc5b in COPD mouse model
by: Song Y, et al.
Published: (2019-09-01)

Two Patients with Dry Eye Disease Followed Up Using an Expression Assay of Ocular Surface Mucin
by: Yumiko Machida, et al.
Published: (2016-04-01)

Change in expression of NFκb and MUC5AC in nasal mucosa during pregnancy
by: Burak Ülkümen, et al.
Published: (2020-09-01)

Understanding the Clinical Impact of MUC5AC Expression on Pancreatic Ductal Adenocarcinoma
by: Ashish Manne, et al.
Published: (2021-06-01)

Effects of guaifenesin, <it>N</it>-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells
by: Seagrave JeanClare, et al.
Published: (2012-10-01)

Effect of Tobacco-specific Nitrosamines on MUC5AC Expression in Human Airway Epithelial Cells
by: Soyoung Kwak, et al.
Published: (2020-05-01)

Upregulation of MUC5AC by VEGF in human primary bronchial epithelial cells: implications for asthma
by: Sung-Ho Kim, et al.
Published: (2019-12-01)

Mucinous colorectal adenocarcinoma: clinical pathology and treatment options
by: Cong Luo, et al.
Published: (2019-03-01)

IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells
by: Yu Xia, et al.
Published: (2017-09-01)

CA 19-9 levels in patients with acute pancreatitis due to gallstone and metabolic/toxic reasons
by: Omer Burcak Binicier, et al.

Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer
by: Leilani Lakemeyer, et al.
Published: (2021-03-01)

Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells
by: Hideaki Shirasaki, et al.
Published: (2015-04-01)

Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection
by: Weronika Gonciarz, et al.
Published: (2019-03-01)

Pic Protein From Enteroaggregative E. coli Induces Different Mechanisms for Its Dual Activity as a Mucus Secretagogue and a Mucinase
by: Fernando Flores-Sanchez, et al.
Published: (2020-11-01)

Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer
by: Ramesh Pothuraju, et al.
Published: (2020-03-01)

Effect of glaucoma drugs joint surgical treatment on patients with tear of MUC5AC and ocular surface
by: Rong-Zhong Zhou
Published: (2013-07-01)

Tepotinib Inhibits the Epithelial–Mesenchymal Transition and Tumor Growth of Gastric Cancers by Increasing GSK3β, E-Cadherin, and Mucin 5AC and 6 Levels
by: Sung-Hwa Sohn, et al.
Published: (2020-08-01)

The role of gastric mucins in interactions with Helicobacter pylori
by: Iwona Radziejewska
Published: (2012-01-01)

Clusterin Induces MUC5AC Expression via Activation of NF-κB in Human Airway Epithelial Cells
by: Chang Hoon Bae, et al.
Published: (2018-06-01)

Polysaccharides and mucin 5AC (MUC5AC) expression in gallbladder mucosa of young patients with gallstones as evaluated by spatial visualization and quantification
by: Aldona Kasprzak, et al.
Published: (2010-04-01)

A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix
by: Hailing Li, et al.
Published: (2020-08-01)

IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway
by: Xiaoping Lai, et al.
Published: (2019-07-01)

Rare primary peritoneal mucinous adenocarcinoma in a 69‐year‐old man
by: Fumiko Satoh, et al.
Published: (2021-09-01)

Short-Term Reproducibility of MUC5AC Measurement in Human Tear Fluid
by: Ashley M. Woodward, et al.
Published: (2021-01-01)

Early Diagnosis of Pancreatic Cancer: The Key for Survival
by: Gina Gheorghe, et al.
Published: (2020-10-01)

The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease
by: Jingyuan Li, et al.
Published: (2020-09-01)

Metastatic prostate cancer with elevated serum levels of CEA and CA19-9
by: Guang-Dar Juang, et al.
Published: (2014-03-01)

Cannot write session to /tmp/vufind_sessions/sess_6f5vpebbfrfe0jvtmve572rd5f