The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma
Li-Zhi Li, Zhuang-Zhuang Wu, Zhi Lv Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, People’s Republic of ChinaCorrespondence: Li-Zhi LiDepartment of Orthopaedics, The Second Hospital of Shanxi Medical University, NO. 382 Wuyi Road, Taiyuan, 030001, Peop...
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doaj-f79b248320254ef197dbd91f96da7e622021-09-28T18:54:47ZengDove Medical PressPharmacogenomics and Personalized Medicine1178-70662021-09-01Volume 141247126169274The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with OsteosarcomaLi LZWu ZZLv ZLi-Zhi Li, Zhuang-Zhuang Wu, Zhi Lv Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, People’s Republic of ChinaCorrespondence: Li-Zhi LiDepartment of Orthopaedics, The Second Hospital of Shanxi Medical University, NO. 382 Wuyi Road, Taiyuan, 030001, People’s Republic of ChinaTel +86 351-3365105Email lzlsun_09dr@aliyun.comObjective: The present study aims to explore the correlation between osteosarcoma (OS) chemosensitivity and the expression levels of serum and tumor tissue micro-ribonucleic acid-21 (miR-21).Methods: The relevant miR-21 expression levels in 30 patients with OS were detected, and the gender, age, tumor location, pathological type, Enneking stage, and miR-21 expression changes before and after chemotherapy were retrospectively analyzed.Results: Serum and tumor tissue miR21 expression levels were significantly higher in patients with OS than in control subjects; the serum miR-21 expressions before and after chemotherapy were not related to patient age and gender. The effective chemotherapy group showed significant differences in miR-21 expression levels before and after chemotherapy.Conclusion: Serum and tumor tissue miR-21 expression levels in patients with OS are closely related to the effects of chemotherapy, making miR-21 a potential biomarker and therapeutic target for the diagnosis and evaluation of chemotherapy effects on patients with OS.Keywords: osteosarcoma, tumor tissue, serum, miR-21, chemotherapyhttps://www.dovepress.com/the-clinical-significance-of-mir-21-in-guiding-chemotherapy-for-patien-peer-reviewed-fulltext-article-PGPMosteosarcomatumor tissueserummir-21chemotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li LZ Wu ZZ Lv Z |
spellingShingle |
Li LZ Wu ZZ Lv Z The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma Pharmacogenomics and Personalized Medicine osteosarcoma tumor tissue serum mir-21 chemotherapy |
author_facet |
Li LZ Wu ZZ Lv Z |
author_sort |
Li LZ |
title |
The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma |
title_short |
The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma |
title_full |
The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma |
title_fullStr |
The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma |
title_full_unstemmed |
The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma |
title_sort |
clinical significance of mir-21 in guiding chemotherapy for patients with osteosarcoma |
publisher |
Dove Medical Press |
series |
Pharmacogenomics and Personalized Medicine |
issn |
1178-7066 |
publishDate |
2021-09-01 |
description |
Li-Zhi Li, Zhuang-Zhuang Wu, Zhi Lv Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, People’s Republic of ChinaCorrespondence: Li-Zhi LiDepartment of Orthopaedics, The Second Hospital of Shanxi Medical University, NO. 382 Wuyi Road, Taiyuan, 030001, People’s Republic of ChinaTel +86 351-3365105Email lzlsun_09dr@aliyun.comObjective: The present study aims to explore the correlation between osteosarcoma (OS) chemosensitivity and the expression levels of serum and tumor tissue micro-ribonucleic acid-21 (miR-21).Methods: The relevant miR-21 expression levels in 30 patients with OS were detected, and the gender, age, tumor location, pathological type, Enneking stage, and miR-21 expression changes before and after chemotherapy were retrospectively analyzed.Results: Serum and tumor tissue miR21 expression levels were significantly higher in patients with OS than in control subjects; the serum miR-21 expressions before and after chemotherapy were not related to patient age and gender. The effective chemotherapy group showed significant differences in miR-21 expression levels before and after chemotherapy.Conclusion: Serum and tumor tissue miR-21 expression levels in patients with OS are closely related to the effects of chemotherapy, making miR-21 a potential biomarker and therapeutic target for the diagnosis and evaluation of chemotherapy effects on patients with OS.Keywords: osteosarcoma, tumor tissue, serum, miR-21, chemotherapy |
topic |
osteosarcoma tumor tissue serum mir-21 chemotherapy |
url |
https://www.dovepress.com/the-clinical-significance-of-mir-21-in-guiding-chemotherapy-for-patien-peer-reviewed-fulltext-article-PGPM |
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