Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
Prime editors use a template sequence within their pegRNA to facilitate nucleotide substitutions or local indels. Here the authors use AAVs to deliver a split-intein prime editor in vivo to correct a pathogenic mutation.
Main Authors: | Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, Wen Xue |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-04-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-22295-w |
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