Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity
The influenza virus protein PA-X modulates the host immune responses and viral pathogenicity through suppression of host protein expression. The endonuclease active site in the N-terminal region, the basic amino acid cluster in the C-terminal PA-X-specific region, and N-terminal acetylation of PA-X...
Main Authors: | Kohei Oishi, Seiya Yamayoshi, Yoshihiro Kawaoka |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-03-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.00432/full |
Similar Items
-
Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins
by: Shuhei Sammaibashi, et al.
Published: (2018-06-01) -
Impact of Influenza A Virus Shutoff Proteins on Host Immune Responses
by: Megan M. Dunagan, et al.
Published: (2021-06-01) -
Closing in on the causes of host shutoff
by: Ian Mohr
Published: (2016-09-01) -
Amino Acid Residues Involved in Inhibition of Host Gene Expression by Influenza A/Brevig Mission/1/1918 PA-X
by: Kevin Chiem, et al.
Published: (2021-05-01) -
Host Shutoff in Influenza A Virus: Many Means to an End
by: Rachel Emily Levene, et al.
Published: (2018-09-01)