SYNTHESIS, CRYSTAL STRUCTURE AND ANTITUMOR ACTIVITY OF A Zn(II) COMPLEX WITH 1,2-PHENYLENEDIOXYDIACETIC ACID

• Main Authors: XI-SHI TAI, JIE YIN, YUAN-YUAN LIU
• Format: Article
• Language: English
• Published: Alma Mater Publishing House "Vasile Alecsandri" University of Bacau 2015-02-01
• Series: Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry
• Subjects: antitumor activity; crystal structure; 1; 2-phenylenedioxydiacetic acid; synthesis; Zn(II) complex
• Online Access: http://pubs.ub.ro/?pg=revues&rev=cscc6&num=201404&vol=4&aid=4171

A novel Zn(II) complex, [Zn(L)(H2O)3]·2H2O, has been obtained by reaction of Zn(OAc)2·2H2O with 1,2-phenylenedioxydiacetic acid in CH3OH/H2O. It was characterized by elemental analysis, IR and X-ray single crystal diffraction analysis. The crystal of the title complex belongs to monoclinic, space group C2/c with a = 29.283(7) Å, b = 6.7305(15) Å, c = 17.243(3) Å, β = 109.25(3)º, V = 3208.4(12) Å3, Z = 8, Dc = 1.621 mg·m-3, μ = 1.590 mm-1, F(000) = 1576, and final R1 = 0.1284, ωR2 = 0.3895. X-ray analysis reveals that the Zn(II) center is seven-coordination with a O7 distorted pengonal bipyramidal coordination environment. The Zn(II) complex molecules form 1D chain structure by the hydrogen bonds and π-π stacking interactions. The antitumor activity of 1,2-phenylenedioxydiacetic acid ligand and its Zn(II) complex against human intestinal adenocarcinoma HCT-8 cells, lung adenocarcinoma HCT-116 cells and human lung adenocarcinoma A549 cells line have been investigated.