Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy
Objective. This study aims to explore the correlations of genetic polymorphisms in LIG4 and HSPB1 genes with the radiation-induced lung injury (RILI), especially radiation pneumonitis (RP), in lung cancer patients. Methods. A total of 160 lung cancer patients, who were diagnosed with inoperable lung...
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doaj-f7ac6c9420f14a1387b2a0c36463a97d2020-11-24T22:27:36ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/860373860373Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with RadiotherapyFeng Xu0Ji-Chang Han1Ya-Jun Zhang2Yi-Jie Zhang3Xiao-Chun Liu4Guan-Bin Qi5Dan Liu6Yan-Zhi Chen7Yu-Xia Zhao8Lu Bai9Department of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaObjective. This study aims to explore the correlations of genetic polymorphisms in LIG4 and HSPB1 genes with the radiation-induced lung injury (RILI), especially radiation pneumonitis (RP), in lung cancer patients. Methods. A total of 160 lung cancer patients, who were diagnosed with inoperable lung cancer and received radiotherapy, were included in the present study from September 2009 to December 2011. TaqMan Real-Time PCR (RT-PCR) was used to verify the SNPs of LIG4 and HSPB1 genes. Chi-square criterion was used to compare the differences in demographic characteristics, exposure to risk factors, and SNPs genotypes. Crude odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated by logistic regression analysis. All statistical analyses were conducted in SPSS 18.0. Results. A total of 32 (20.0%) lung cancer patients had RP after receiving radiotherapy. Of the 32 cases, 4 cases were of grade 2, 24 cases were of grade 3, and 4 cases were of grade 4. However, our results indicated that the general condition and treatment of all patients had no significant difference with RP risk (P>0.05). Meanwhile, our results revealed that there was no significant association between the frequencies of LIG4 rs1805388 and HSPB1 rs2868371 genotype distribution and the risk of RP (P>0.05). Conclusion. In conclusion, we demonstrated that the genetic polymorphisms in LIG4 rs1805388 and HSPB1 rs2868371 were not obviously correlated with the risk of RP and RILI of lung cancer.http://dx.doi.org/10.1155/2015/860373 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feng Xu Ji-Chang Han Ya-Jun Zhang Yi-Jie Zhang Xiao-Chun Liu Guan-Bin Qi Dan Liu Yan-Zhi Chen Yu-Xia Zhao Lu Bai |
spellingShingle |
Feng Xu Ji-Chang Han Ya-Jun Zhang Yi-Jie Zhang Xiao-Chun Liu Guan-Bin Qi Dan Liu Yan-Zhi Chen Yu-Xia Zhao Lu Bai Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy BioMed Research International |
author_facet |
Feng Xu Ji-Chang Han Ya-Jun Zhang Yi-Jie Zhang Xiao-Chun Liu Guan-Bin Qi Dan Liu Yan-Zhi Chen Yu-Xia Zhao Lu Bai |
author_sort |
Feng Xu |
title |
Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy |
title_short |
Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy |
title_full |
Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy |
title_fullStr |
Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy |
title_full_unstemmed |
Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy |
title_sort |
associations of lig4 and hspb1 genetic polymorphisms with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Objective. This study aims to explore the correlations of genetic polymorphisms in LIG4 and HSPB1 genes with the radiation-induced lung injury (RILI), especially radiation pneumonitis (RP), in lung cancer patients. Methods. A total of 160 lung cancer patients, who were diagnosed with inoperable lung cancer and received radiotherapy, were included in the present study from September 2009 to December 2011. TaqMan Real-Time PCR (RT-PCR) was used to verify the SNPs of LIG4 and HSPB1 genes. Chi-square criterion was used to compare the differences in demographic characteristics, exposure to risk factors, and SNPs genotypes. Crude odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated by logistic regression analysis. All statistical analyses were conducted in SPSS 18.0. Results. A total of 32 (20.0%) lung cancer patients had RP after receiving radiotherapy. Of the 32 cases, 4 cases were of grade 2, 24 cases were of grade 3, and 4 cases were of grade 4. However, our results indicated that the general condition and treatment of all patients had no significant difference with RP risk (P>0.05). Meanwhile, our results revealed that there was no significant association between the frequencies of LIG4 rs1805388 and HSPB1 rs2868371 genotype distribution and the risk of RP (P>0.05). Conclusion. In conclusion, we demonstrated that the genetic polymorphisms in LIG4 rs1805388 and HSPB1 rs2868371 were not obviously correlated with the risk of RP and RILI of lung cancer. |
url |
http://dx.doi.org/10.1155/2015/860373 |
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