Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent

Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent

B-cell lymphoma 2 (BCL-2) family proteins primarily work as a programmed cell death regulator, whereby multiple interactions between them determine cell survival. This explains the two major classes of BCL-2 proteins which are anti-apoptotic and pro-apoptotic proteins. The anti-apoptotic proteins ar...

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Bibliographic Details
Main Authors:	Nur Najmi Mohamad Anuar, Nur Syahidah Nor Hisam, Sze Ling Liew, Azizah Ugusman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Pharmacology
Subjects:	anti-cancer agent apoptosis cancer fibrosis navitoclax (ABT-263) B-cell lymphoma
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.564108/full

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