Breast Radiotherapy-Related Cardiotoxicity. When, How, Why. Risk Prevention and Control Strategies

• Main Authors: Ana Aurora Díaz-Gavela, Lourdes Figueiras-Graillet, Ángel Montero Luis, Juliana Salas Segura, Raquel Ciérvide, Elia del Cerro Peñalver, Felipe Couñago, Meritxell Arenas, Teresa López-Fernández
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Cancers
• Subjects: breast cancer radiotherapy; cardio-oncology; radiation-induced heart disease; cardiovascular risk; prevention; cardiotoxicity
• Online Access: https://www.mdpi.com/2072-6694/13/7/1712

In recent decades, improvements in breast cancer management have increased overall patient survival; however, many cancer therapies have been linked to an important risk of cardiovascular adverse events. Cardio-oncology has been proposed as an emerging specialty to coordinate preventive strategies that improve the cardiovascular health of oncologic patients. It employs the most suitable personalized multidisciplinary management approach for each patient to optimize their cardiovascular health and improve their survival and quality of life. Radiotherapy is an essential part of the therapeutic regimen in breast cancer patients but can also increase the risk of cardiovascular disease. Therefore, minimizing the negative impact of radiation therapy is an important challenge for radiotherapy oncologists and cardiologists specializing in this field. The aim of the present review is to update our knowledge about radiation-induced cardiotoxicity in breast cancer patients by undertaking a critical review of the relevant literature to determine risk prevention and control strategies currently available.