Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis
We present the case of a patient with Epstein-Barr virus (EBV) encephalitis who developed abnormal white matter lesions during the chronic phases of the infection. A 2-year-old-boy was admitted for a 2 day history of decreased activity with ataxic gait. The results of the physical examination were u...
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doaj-f7b74a04ce254356ae9f3629d73bf2ec2020-11-24T23:11:36ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582011-09-0154938939310.3345/kjp.2011.54.9.3892011540907Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitisYoon Young Jang0Kye Hyang Lee1Department of Pediatrics, Catholic University of Daegu School of Medicine, Daegu, Korea.Department of Pediatrics, Catholic University of Daegu School of Medicine, Daegu, Korea.We present the case of a patient with Epstein-Barr virus (EBV) encephalitis who developed abnormal white matter lesions during the chronic phases of the infection. A 2-year-old-boy was admitted for a 2 day history of decreased activity with ataxic gait. The results of the physical examination were unremarkable except for generalized lethargy and enlarged tonsils with exudates. Brain magnetic resonance imaging (MRI) at admission showed multiple high signal intensities in both basal ganglia and thalami. The result of EBV polymerase chain reaction (PCR) of the cerebral spinal fluid was positive, and a serological test showed acute EBV infection. The patient was diagnosed with EBV encephalitis and recovered fully without any residual neurologic complications. Subsequently, follow-up MRI at 5 weeks revealed extensive periventricular white matter lesions. Since the patient remained clinically stable and asymptomatic during the follow-up period, no additional studies were performed and no additional treatments were provided. At the 1-year follow-up, cranial MRI showed complete disappearance of the abnormal high signal intensities previously seen in the white matter. The patient continued to remain healthy with no focal neurologic deficits on examination. This is the first case of asymptomatic self-limited white matter lesions seen in serial MRI studies in a Korean boy with EBV encephalitis.http://kjp.or.kr/upload/pdf/kjped-54-389.pdfEpstein-Barr virusEncephalitisWhite matterMagnetic resonance imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoon Young Jang Kye Hyang Lee |
spellingShingle |
Yoon Young Jang Kye Hyang Lee Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis Korean Journal of Pediatrics Epstein-Barr virus Encephalitis White matter Magnetic resonance imaging |
author_facet |
Yoon Young Jang Kye Hyang Lee |
author_sort |
Yoon Young Jang |
title |
Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis |
title_short |
Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis |
title_full |
Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis |
title_fullStr |
Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis |
title_full_unstemmed |
Transient asymptomatic white matter lesions following Epstein-Barr virus encephalitis |
title_sort |
transient asymptomatic white matter lesions following epstein-barr virus encephalitis |
publisher |
Korean Pediatric Society |
series |
Korean Journal of Pediatrics |
issn |
1738-1061 2092-7258 |
publishDate |
2011-09-01 |
description |
We present the case of a patient with Epstein-Barr virus (EBV) encephalitis who developed abnormal white matter lesions during the chronic phases of the infection. A 2-year-old-boy was admitted for a 2 day history of decreased activity with ataxic gait. The results of the physical examination were unremarkable except for generalized lethargy and enlarged tonsils with exudates. Brain magnetic resonance imaging (MRI) at admission showed multiple high signal intensities in both basal ganglia and thalami. The result of EBV polymerase chain reaction (PCR) of the cerebral spinal fluid was positive, and a serological test showed acute EBV infection. The patient was diagnosed with EBV encephalitis and recovered fully without any residual neurologic complications. Subsequently, follow-up MRI at 5 weeks revealed extensive periventricular white matter lesions. Since the patient remained clinically stable and asymptomatic during the follow-up period, no additional studies were performed and no additional treatments were provided. At the 1-year follow-up, cranial MRI showed complete disappearance of the abnormal high signal intensities previously seen in the white matter. The patient continued to remain healthy with no focal neurologic deficits on examination. This is the first case of asymptomatic self-limited white matter lesions seen in serial MRI studies in a Korean boy with EBV encephalitis. |
topic |
Epstein-Barr virus Encephalitis White matter Magnetic resonance imaging |
url |
http://kjp.or.kr/upload/pdf/kjped-54-389.pdf |
work_keys_str_mv |
AT yoonyoungjang transientasymptomaticwhitematterlesionsfollowingepsteinbarrvirusencephalitis AT kyehyanglee transientasymptomaticwhitematterlesionsfollowingepsteinbarrvirusencephalitis |
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