Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

The etiology of focal cortical dysplasia (FCD) is not fully understood. Here authors generate an mTORC1 overactivation mouse model that recapitulates hallmarks of type II FCDs, including spontaneous seizures, and suggest that neuronal defects, rather than macrostructural changes, lead to seizures.

Bibliographic Details
Main Authors: Lawrence S. Hsieh, John H. Wen, Kumiko Claycomb, Yuegao Huang, Felicia A. Harrsch, Janice R. Naegele, Fahmeed Hyder, Gordon F. Buchanan, Angelique Bordey
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11753

Internet

https://doi.org/10.1038/ncomms11753

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