NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury

Abstract Background Brain injury is the leading cause of death and disability in survivors of cardiac arrest, where neuroinflammation is believed to play a pivotal role, but the underlying mechanism remains unclear. Pyroptosis is a pro-inflammatory form of programmed cell death that triggers inflamm...

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Bibliographic Details
Main Authors: Yuan Chang, Juan Zhu, Di Wang, Hua Li, Yihua He, Kewei Liu, Xiaoqiang Wang, Yuqin Peng, Suyue Pan, Kaibin Huang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
Cardiac arrest
Caspase-1
Microglia
NLRP3
Pyroptosis
Online Access:http://link.springer.com/article/10.1186/s12974-020-01879-1

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