Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is asso...
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doaj-f7bfe2cbbfc04087a933a3ae2d2c01122021-07-15T15:39:21ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-01102903290310.3390/jcm10132903Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19Jiezhong Chen0Luis Vitetta1Medlab Clinical, Research Department, Sydney 2015, AustraliaMedlab Clinical, Research Department, Sydney 2015, AustraliaThe gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms.https://www.mdpi.com/2077-0383/10/13/2903COVID-19intestinal dysbiosisbutyrateprobioticsnutraceuticals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiezhong Chen Luis Vitetta |
spellingShingle |
Jiezhong Chen Luis Vitetta Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 Journal of Clinical Medicine COVID-19 intestinal dysbiosis butyrate probiotics nutraceuticals |
author_facet |
Jiezhong Chen Luis Vitetta |
author_sort |
Jiezhong Chen |
title |
Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_short |
Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_full |
Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_fullStr |
Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_full_unstemmed |
Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_sort |
modulation of gut microbiota for the prevention and treatment of covid-19 |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-06-01 |
description |
The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms. |
topic |
COVID-19 intestinal dysbiosis butyrate probiotics nutraceuticals |
url |
https://www.mdpi.com/2077-0383/10/13/2903 |
work_keys_str_mv |
AT jiezhongchen modulationofgutmicrobiotaforthepreventionandtreatmentofcovid19 AT luisvitetta modulationofgutmicrobiotaforthepreventionandtreatmentofcovid19 |
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1721299164255485952 |