Anaplastic lymphoma kinase positive variant of anaplastic large cell lymphoma: A rare entity

• Main Authors: Venkata Satya Ramesh Thummala, Sreenidhi Banda, Vinay Kumar Reddy Kundoor, Kotya Naik Maloth
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-01-01
• Series: Journal of Indian Academy of Oral Medicine and Radiology
• Subjects: Anaplastic lymphoma kinase positive; B-cell lineage; CD30 positive; lymphoma; non-Hodgkin′s lymphoma; Reed-Sternberg cells
• Online Access: http://www.jiaomr.in/article.asp?issn=0972-1363;year=2014;volume=26;issue=4;spage=432;epage=435;aulast=Thummala

Anaplastic large cell lymphoma (ALCL) is a distinct clinicopathological entity of non-Hodgkin′s lymphoma, which has been included as a T-cell neoplasm in the World Health Organization classification, with peculiar features such as painless lymphadenopathy, swelling of extranodal and endoreticular organs, intraoral swellings, and characteristic hallmark cells (eccentric, kidney-shaped, or horseshoe-shaped nuclei) and cluster of differentiation 30 (CD30) positivity. Thorough clinical, biochemical, immunohistochemical, histopathological, and radiological evaluation aids in accurate diagnosis and management of the disease. Here, we report a case of anaplastic lymphoma kinase positive variant of ALCL in a 13-year-old boy.