Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease
Follicular lymphoma (FL) with hyaline-vascular Castleman disease (FL-HVCD)-like features is a rare morphologic variant, with fewer than 20 cases in the literature. Herein, we report a case of FL-HVCD in a 37-year-old female who presented with isolated neck lymph node enlargement. The excised lymph n...
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Korean Society of Pathologists & the Korean Society for Cytopathology
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doaj-f7cb3a92092d49419bbd7dbad3b3760a2020-11-25T03:21:55ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452020-05-0154325325710.4132/jptm.2019.12.1716891Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman diseaseJiwon Koh0Yoon Kyung Jeon1 Department of Pathology, Seoul National University Hospital, Seoul, Korea Department of Pathology, Seoul National University Hospital, Seoul, KoreaFollicular lymphoma (FL) with hyaline-vascular Castleman disease (FL-HVCD)-like features is a rare morphologic variant, with fewer than 20 cases in the literature. Herein, we report a case of FL-HVCD in a 37-year-old female who presented with isolated neck lymph node enlargement. The excised lymph node showed features reminiscent of HVCD, including regressed germinal centers (GCs) surrounded by onion skin-like mantle zones, lollipop lesions composed of hyalinized blood vessels penetrating into regressed GCs, and hyalinized interfollicular stroma. In addition, focal areas of abnormally conglomerated GCs composed of homogeneous, small centrocytes with strong BCL2, CD10, and BCL6 expression were observed, indicating partial involvement of the FL. Several other lymphoid follicles showed features of in situ follicular neoplasia. Based on the observations, a diagnosis of FL-HVCD was made. Although FLHVCD is very rare, the possibility of this variant should be considered in cases resembling CD. Identification of abnormal, neoplastic follicles and ancillary immunostaining are helpful for proper diagnosis.http://www.jpatholtm.org/upload/pdf/jptm-2019-12-17.pdfmalignant lymphomafollicular lymphomahyaline-vascular castleman diseasein situ follicular neoplasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiwon Koh Yoon Kyung Jeon |
spellingShingle |
Jiwon Koh Yoon Kyung Jeon Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease Journal of Pathology and Translational Medicine malignant lymphoma follicular lymphoma hyaline-vascular castleman disease in situ follicular neoplasia |
author_facet |
Jiwon Koh Yoon Kyung Jeon |
author_sort |
Jiwon Koh |
title |
Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease |
title_short |
Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease |
title_full |
Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease |
title_fullStr |
Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease |
title_full_unstemmed |
Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease |
title_sort |
morphologic variant of follicular lymphoma reminiscent of hyaline-vascular castleman disease |
publisher |
Korean Society of Pathologists & the Korean Society for Cytopathology |
series |
Journal of Pathology and Translational Medicine |
issn |
2383-7837 2383-7845 |
publishDate |
2020-05-01 |
description |
Follicular lymphoma (FL) with hyaline-vascular Castleman disease (FL-HVCD)-like features is a rare morphologic variant, with fewer than 20 cases in the literature. Herein, we report a case of FL-HVCD in a 37-year-old female who presented with isolated neck lymph node enlargement. The excised lymph node showed features reminiscent of HVCD, including regressed germinal centers (GCs) surrounded by onion skin-like mantle zones, lollipop lesions composed of hyalinized blood vessels penetrating into regressed GCs, and hyalinized interfollicular stroma. In addition, focal areas of abnormally conglomerated GCs composed of homogeneous, small centrocytes with strong BCL2, CD10, and BCL6 expression were observed, indicating partial involvement of the FL. Several other lymphoid follicles showed features of in situ follicular neoplasia. Based on the observations, a diagnosis of FL-HVCD was made. Although FLHVCD is very rare, the possibility of this variant should be considered in cases resembling CD. Identification of abnormal, neoplastic follicles and ancillary immunostaining are helpful for proper diagnosis. |
topic |
malignant lymphoma follicular lymphoma hyaline-vascular castleman disease in situ follicular neoplasia |
url |
http://www.jpatholtm.org/upload/pdf/jptm-2019-12-17.pdf |
work_keys_str_mv |
AT jiwonkoh morphologicvariantoffollicularlymphomareminiscentofhyalinevascularcastlemandisease AT yoonkyungjeon morphologicvariantoffollicularlymphomareminiscentofhyalinevascularcastlemandisease |
_version_ |
1724612415356665856 |