WNT Signaling in Hematological Malignancies
The role of the WNT signaling pathway in key cellular processes, such as cell proliferation, differentiation and migration is well documented. WNT signaling cascade is initiated by the interaction of WNT ligands with receptors belonging to the Frizzled family, and/or the ROR1/ROR2 and RYK families....
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2020-12-01
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doaj-f7dfaf19cccd4e86898e79c71d0cb6ae2020-12-21T07:23:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.615190615190WNT Signaling in Hematological MalignanciesMichela Frenquelli0Michela Frenquelli1Giovanni Tonon2Giovanni Tonon3B-cell Neoplasia Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, ItalyFunctional Genomics of Cancer Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, ItalyFunctional Genomics of Cancer Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, ItalyCenter for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, ItalyThe role of the WNT signaling pathway in key cellular processes, such as cell proliferation, differentiation and migration is well documented. WNT signaling cascade is initiated by the interaction of WNT ligands with receptors belonging to the Frizzled family, and/or the ROR1/ROR2 and RYK families. The downstream signaling cascade results in the activation of the canonical β-catenin dependent pathway, ultimately leading to transcriptional control of cell proliferation, or the non-canonical pathway, mainly acting on cell migration and cell polarity. The high level of expression of both WNT ligands and WNT receptors in cancer cells and in the surrounding microenvironment suggests that WNT may represent a central conduit of interactions between tumor cells and microenviroment. In this review we will focus on WNT pathways deregulation in hematological cancers, both at the ligand and receptor levels. We will review available literature regarding both the classical β-catenin dependent pathway as well as the non-canonical pathway, with particular emphasis on the possible exploitation of WNT aberrant activation as a therapeutic target, a notion supported by preclinical data.https://www.frontiersin.org/articles/10.3389/fonc.2020.615190/fullmultiple myelomaWNTROR2Wnt/b-cateninmicroenvironment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michela Frenquelli Michela Frenquelli Giovanni Tonon Giovanni Tonon |
spellingShingle |
Michela Frenquelli Michela Frenquelli Giovanni Tonon Giovanni Tonon WNT Signaling in Hematological Malignancies Frontiers in Oncology multiple myeloma WNT ROR2 Wnt/b-catenin microenvironment |
author_facet |
Michela Frenquelli Michela Frenquelli Giovanni Tonon Giovanni Tonon |
author_sort |
Michela Frenquelli |
title |
WNT Signaling in Hematological Malignancies |
title_short |
WNT Signaling in Hematological Malignancies |
title_full |
WNT Signaling in Hematological Malignancies |
title_fullStr |
WNT Signaling in Hematological Malignancies |
title_full_unstemmed |
WNT Signaling in Hematological Malignancies |
title_sort |
wnt signaling in hematological malignancies |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-12-01 |
description |
The role of the WNT signaling pathway in key cellular processes, such as cell proliferation, differentiation and migration is well documented. WNT signaling cascade is initiated by the interaction of WNT ligands with receptors belonging to the Frizzled family, and/or the ROR1/ROR2 and RYK families. The downstream signaling cascade results in the activation of the canonical β-catenin dependent pathway, ultimately leading to transcriptional control of cell proliferation, or the non-canonical pathway, mainly acting on cell migration and cell polarity. The high level of expression of both WNT ligands and WNT receptors in cancer cells and in the surrounding microenvironment suggests that WNT may represent a central conduit of interactions between tumor cells and microenviroment. In this review we will focus on WNT pathways deregulation in hematological cancers, both at the ligand and receptor levels. We will review available literature regarding both the classical β-catenin dependent pathway as well as the non-canonical pathway, with particular emphasis on the possible exploitation of WNT aberrant activation as a therapeutic target, a notion supported by preclinical data. |
topic |
multiple myeloma WNT ROR2 Wnt/b-catenin microenvironment |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.615190/full |
work_keys_str_mv |
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