Crystal structure-guided design of berberine-based novel chitinase inhibitors

Crystal structure-guided design of berberine-based novel chitinase inhibitors

Glycoside hydrolase family 18 (GH18) chitinases play an important role in various organisms ranging from bacteria to mammals. Chitinase inhibitors have potential applications as pesticides, fungicides, and anti-asthmatics. Berberine, a plant-derived isoquinoline alkaloid, was previously reported to...

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Bibliographic Details
Main Authors:	Lei Chen, Ling Zhu, Jinli Chen, Wei Chen, Xuhong Qian, Qing Yang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	berberine chitinase inhibitor structural optimisation
Online Access:	http://dx.doi.org/10.1080/14756366.2020.1837123

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