Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life

Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life

Prior evidence suggested mesenchymal stromal cells (MSCs) required for skeletal formation, maintenance, and repair arise postnatally. Here, the authors show that Hoxa11 lineage-marked cells give rise to all skeletal lineages from embryogenesis through adulthood and are upstream progenitors of LepR-...

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Main Authors: Kyriel M. Pineault, Jane Y. Song, Kenneth M. Kozloff, Daniel Lucas, Deneen M. Wellik
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11100-4
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spelling doaj-f7ea0e26660043b5baab7d27f61badf52021-05-11T11:53:32ZengNature Publishing GroupNature Communications2041-17232019-07-0110111510.1038/s41467-019-11100-4Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout lifeKyriel M. Pineault0Jane Y. Song1Kenneth M. Kozloff2Daniel Lucas3Deneen M. Wellik4Department of Cell & Regenerative Biology, University of Wisconsin-MadisonCellular and Molecular Biology Program, University of MichiganDepartment of Orthopedic Surgery, University of MichiganDivision of Experimental Hematology and Cancer Research, Cincinnati Children’s Medical CenterDepartment of Cell & Regenerative Biology, University of Wisconsin-MadisonPrior evidence suggested mesenchymal stromal cells (MSCs) required for skeletal formation, maintenance, and repair arise postnatally. Here, the authors show that Hoxa11 lineage-marked cells give rise to all skeletal lineages from embryogenesis through adulthood and are upstream progenitors of LepR- and Osx-lineage MSCshttps://doi.org/10.1038/s41467-019-11100-4
collection DOAJ
language English
format Article
sources DOAJ
author Kyriel M. Pineault
Jane Y. Song
Kenneth M. Kozloff
Daniel Lucas
Deneen M. Wellik
spellingShingle Kyriel M. Pineault
Jane Y. Song
Kenneth M. Kozloff
Daniel Lucas
Deneen M. Wellik
Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
Nature Communications
author_facet Kyriel M. Pineault
Jane Y. Song
Kenneth M. Kozloff
Daniel Lucas
Deneen M. Wellik
author_sort Kyriel M. Pineault
title Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
title_short Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
title_full Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
title_fullStr Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
title_full_unstemmed Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
title_sort hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-07-01
description Prior evidence suggested mesenchymal stromal cells (MSCs) required for skeletal formation, maintenance, and repair arise postnatally. Here, the authors show that Hoxa11 lineage-marked cells give rise to all skeletal lineages from embryogenesis through adulthood and are upstream progenitors of LepR- and Osx-lineage MSCs
url https://doi.org/10.1038/s41467-019-11100-4
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