Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life
Prior evidence suggested mesenchymal stromal cells (MSCs) required for skeletal formation, maintenance, and repair arise postnatally. Here, the authors show that Hoxa11 lineage-marked cells give rise to all skeletal lineages from embryogenesis through adulthood and are upstream progenitors of LepR-...
Main Authors: | Kyriel M. Pineault, Jane Y. Song, Kenneth M. Kozloff, Daniel Lucas, Deneen M. Wellik |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11100-4 |
Similar Items
-
Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation
by: Kyriel M. Pineault, et al.
Published: (2015-11-01) -
Hox genes maintain critical roles in the adult skeleton
by: Song, Jane Y., et al.
Published: (2020) -
Hox genes and evolution [version 1; referees: 3 approved]
by: Steven M. Hrycaj, et al.
Published: (2016-05-01) -
Two CRISPR/Cas9-mediated methods for targeting complex insertions, deletions, or replacements in mouse
by: Kyriel M. Pineault, et al.
Published: (2019-01-01) -
Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones
by: Dion Giovannone, et al.
Published: (2019-02-01)