Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction

Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction

The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflammation, and fibrosis following myocardial infarction (MI) in vivo. Little is known, however, regarding the cardioprotective actions of the N-terminal-derived peptide of ann...

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Bibliographic Details
Main Authors: Cheng Xue Qin, Sarah Rosli, Minh Deo, Nga Cao, Jesse Walsh, Mitchel Tate, Amy E. Alexander, Daniel Donner, Duncan Horlock, Renming Li, Helen Kiriazis, Man K. S. Lee, Jane E. Bourke, Yuan Yang, Andrew J. Murphy, Xiao-Jun Du, Xiao Ming Gao, Rebecca H. Ritchie
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
myocardial ischemia
inflammation
cardiac remodeling
annexin-A1
formyl peptide receptors
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00269/full

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