Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis

Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis

Abstract Pannexin1 (PANX1) is a large-pore ATP efflux channel with a broad distribution, which allows the exchange of molecules and ions smaller than 1 kDa between the cytoplasm and extracellular space. In this study, we show that in human macrophages PANX1 expression is upregulated by diverse stimu...

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Bibliographic Details
Main Authors: Sensen Zhang, Baolei Yuan, Jordy Homing Lam, Jun Zhou, Xuan Zhou, Gerardo Ramos-Mandujano, Xueyuan Tian, Yang Liu, Renmin Han, Yu Li, Xin Gao, Mo Li, Maojun Yang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00259-0

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