Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
Peidang Liu,1,2 Haizhen Jin,1 Zhirui Guo,3 Jun Ma,4 Jing Zhao,1 Dongdong Li,1 Hao Wu,2 Ning Gu2 1School of Medicine, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 3The Second Affiliated Hospital of Nanjing Medical University, 4Tr...
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doaj-f7f57ff6797542bd804ac5022737f6b32020-11-24T21:04:32ZengDove Medical PressInternational Journal of Nanomedicine1178-20132016-10-01Volume 115003501429237Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of gliomaLiu PDJin HGuo ZMa JZhao JLi DWu HGu NPeidang Liu,1,2 Haizhen Jin,1 Zhirui Guo,3 Jun Ma,4 Jing Zhao,1 Dongdong Li,1 Hao Wu,2 Ning Gu2 1School of Medicine, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 3The Second Affiliated Hospital of Nanjing Medical University, 4Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, People’s Republic of China Abstract: Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma. Keywords: gold nanoparticles, silver nanoparticles, radiosensitization, glioma, apoptosis, autophagyhttps://www.dovepress.com/silver-nanoparticles-outperform-gold-nanoparticles-in-radiosensitizing-peer-reviewed-article-IJNGold nanoparticlessilver nanoparticlesradiosensitizationgliomaapoptosisautophagy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liu PD Jin H Guo Z Ma J Zhao J Li D Wu H Gu N |
spellingShingle |
Liu PD Jin H Guo Z Ma J Zhao J Li D Wu H Gu N Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma International Journal of Nanomedicine Gold nanoparticles silver nanoparticles radiosensitization glioma apoptosis autophagy |
author_facet |
Liu PD Jin H Guo Z Ma J Zhao J Li D Wu H Gu N |
author_sort |
Liu PD |
title |
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma |
title_short |
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma |
title_full |
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma |
title_fullStr |
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma |
title_full_unstemmed |
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma |
title_sort |
silver nanoparticles outperform gold nanoparticles in radiosensitizing u251 cells in vitro and in an intracranial mouse model of glioma |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2016-10-01 |
description |
Peidang Liu,1,2 Haizhen Jin,1 Zhirui Guo,3 Jun Ma,4 Jing Zhao,1 Dongdong Li,1 Hao Wu,2 Ning Gu2 1School of Medicine, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 3The Second Affiliated Hospital of Nanjing Medical University, 4Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, People’s Republic of China Abstract: Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma. Keywords: gold nanoparticles, silver nanoparticles, radiosensitization, glioma, apoptosis, autophagy |
topic |
Gold nanoparticles silver nanoparticles radiosensitization glioma apoptosis autophagy |
url |
https://www.dovepress.com/silver-nanoparticles-outperform-gold-nanoparticles-in-radiosensitizing-peer-reviewed-article-IJN |
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