Bortezomib in combination with low-dose oral melphalan, dexamethasone and thalidomide for relapsed elderly patients with multiple myeloma

• Main Authors: Taleb Azarm, Mojtaba Akbari, Arezo Azarm, Hamid Mohager
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2012-01-01
• Series: Journal of Research in Medical Sciences
• Subjects: Multiple Myeloma; Bortezomib; Dexamethasone; Melphalan; Thalidomide
• Online Access: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=1;spage=8;epage=14;aulast=Azarm

Background: The aim of the study was to assess the effects of combination of bortezomib moderate dose and conti-nuous oral low dose melphalan and thalidomide and dexamethasone (BMTD regimen) in elderly patients aged ≥ 65 years with relapsed multiple myeloma (MM). Methods: Twenty four patients with advanced MM were enrolled to receive eight 3-week treatment cycles with borte-zomib 1.3 mg/m2 on days 1, 4, 8, and 11 followed by three 5-week cycles with bortezomib 1.3 mg/m2 on days 1, 8, 15, and 22. Within all cycles, dexamethasone 24 mg/d was given intravenously on the day of bortezomib injection and the day thereafter. In addition, patients received oral treatment of melphalan at a dose of 5 mg/d continuously for twenty days for every cycle. Results: Mean age of study patients was 72.8 ΁ 6.4 years. All patients that completed at least one treatment cycle were evaluated for response. Complete, partial, and minor responses occurred in 19%, 65% and 6% of patients, respectively. Overall response rate was 90% (efficacy analysis). Conclusions: This study demonstrated potent in vivo activity of combination therapy with BMTD regimen in patients with relapsed MM, with an acceptable safety profile and high overall response rate.