Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patients
Low 25-OH vitamin D levels have been linked to peritonitis and cardiovascular mortality in peritoneal dialysis (PD) patients. In this study we aimed to investigate the association of 25-OH vitamin D levels with peritoneal membrane characteristics in chronic PD patients. Consecutive 103 PD patients w...
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doaj-f7f824fec4ba4030b279d18c73c963532021-09-26T14:34:43ZengSociety of TURAZ AKADEMI Medicine Science2147-06342021-09-0110310263010.5455/medscience.2021.03.08263675Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patientsDilek Barutcu Atas0Basar Aykent1Hakki Arikan2Murat Tugcu3Arzu Velioglu4Ebru Asicioglu5Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul City, Turkey. Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul City, Turkey. Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul City, Turkey. Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul City, Turkey. Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul City, Turkey. Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul City, Turkey.Low 25-OH vitamin D levels have been linked to peritonitis and cardiovascular mortality in peritoneal dialysis (PD) patients. In this study we aimed to investigate the association of 25-OH vitamin D levels with peritoneal membrane characteristics in chronic PD patients. Consecutive 103 PD patients were enrolled in this retrospective study. Peritoneal dialysate to plasma (D/P) creatinine increase more than 0.1 with time were accepted as significant according Roc curve analysis. Patients with and without an increase in the D/P creatinine ratio of 0.1 were classified as Group 1 and Group 2, respectively. The relationship between baseline 25-OH vitamin D and peritoneal membrane characteristics were investigated. Mean age of the patients was 53.4±14.9 years and duration of PD was 72.1±50.3 months. There were thirty (29.1%) patients in Group 1. The duration of PD [73.5 (52.3-133.8) vs 49.0 (33.5-94.0) months, p:0.008]; hemoglobin [11.4 (10.4-12.2) vs. 10.2 (9.4-11.0) g/dL, p:0.001]and PTH [500.5 (254.5-748.3) vs 329.0 (205.0-549.5)ng/mL, p:0.047] levels were significantly higher in Group 1, whereas 25-OH vitamin D levels [5.0 (3.0-9.3) vs 7.8 (4.5-11.1)μg/L, p:0.027] and CRP [4.0 (3.0-7.2) vs. 8.0 (3.0-13.5)mg/L, p:0.028] were significantly lower. Multivariate analysis revealed duration of PD [Exp(B):1.012 (95%CI:1.001-1.022), p:0.028]; hemoglobin [Exp(B):1.756 (95%CI:1.199-2.571), p:0.004]; C-reactive protein (CRP) [Exp(B):0.882 (95%CI:0.789-0.985), p:0.026] and 25-OH vitamin D [Exp(B):0.853 (95%CI:0.754-0.965), p:0.012] were independent predictors of an increase in D/P creatinine ratio in PD patients. Increased D/P creatinine ratio was negatively correlated with 25-OH vitamin D level (r: -0.217, p:0.028). Lower levels of initial 25-OH vitamin D were associated with an increase in D/P creatinine ratio over-time. [Med-Science 2021; 10(3.000): 1026-30]http://www.ejmanager.com/fulltextpdf.php?mno=63675inflammation25-oh vitamin dchronic kidney diseased/p creatinine ratioperitoneal dialysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dilek Barutcu Atas Basar Aykent Hakki Arikan Murat Tugcu Arzu Velioglu Ebru Asicioglu |
spellingShingle |
Dilek Barutcu Atas Basar Aykent Hakki Arikan Murat Tugcu Arzu Velioglu Ebru Asicioglu Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patients Medicine Science inflammation 25-oh vitamin d chronic kidney disease d/p creatinine ratio peritoneal dialysis |
author_facet |
Dilek Barutcu Atas Basar Aykent Hakki Arikan Murat Tugcu Arzu Velioglu Ebru Asicioglu |
author_sort |
Dilek Barutcu Atas |
title |
Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patients |
title_short |
Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patients |
title_full |
Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patients |
title_fullStr |
Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patients |
title_full_unstemmed |
Low serum 25-OH vitamin D levels are associated with increased D/P creatinine ratio in peritoneal dialysis patients |
title_sort |
low serum 25-oh vitamin d levels are associated with increased d/p creatinine ratio in peritoneal dialysis patients |
publisher |
Society of TURAZ AKADEMI |
series |
Medicine Science |
issn |
2147-0634 |
publishDate |
2021-09-01 |
description |
Low 25-OH vitamin D levels have been linked to peritonitis and cardiovascular mortality in peritoneal dialysis (PD) patients. In this study we aimed to investigate the association of 25-OH vitamin D levels with peritoneal membrane characteristics in chronic PD patients. Consecutive 103 PD patients were enrolled in this retrospective study. Peritoneal dialysate to plasma (D/P) creatinine increase more than 0.1 with time were accepted as significant according Roc curve analysis. Patients with and without an increase in the D/P creatinine ratio of 0.1 were classified as Group 1 and Group 2, respectively. The relationship between baseline 25-OH vitamin D and peritoneal membrane characteristics were investigated. Mean age of the patients was 53.4±14.9 years and duration of PD was 72.1±50.3 months. There were thirty (29.1%) patients in Group 1. The duration of PD [73.5 (52.3-133.8) vs 49.0 (33.5-94.0) months, p:0.008]; hemoglobin [11.4 (10.4-12.2) vs. 10.2 (9.4-11.0) g/dL, p:0.001]and PTH [500.5 (254.5-748.3) vs 329.0 (205.0-549.5)ng/mL, p:0.047] levels were significantly higher in Group 1, whereas 25-OH vitamin D levels [5.0 (3.0-9.3) vs 7.8 (4.5-11.1)μg/L, p:0.027] and CRP [4.0 (3.0-7.2) vs. 8.0 (3.0-13.5)mg/L, p:0.028] were significantly lower. Multivariate analysis revealed duration of PD [Exp(B):1.012 (95%CI:1.001-1.022), p:0.028]; hemoglobin [Exp(B):1.756 (95%CI:1.199-2.571), p:0.004]; C-reactive protein (CRP) [Exp(B):0.882 (95%CI:0.789-0.985), p:0.026] and 25-OH vitamin D [Exp(B):0.853 (95%CI:0.754-0.965), p:0.012] were independent predictors of an increase in D/P creatinine ratio in PD patients. Increased D/P creatinine ratio was negatively correlated with 25-OH vitamin D level (r: -0.217, p:0.028). Lower levels of initial 25-OH vitamin D were associated with an increase in D/P creatinine ratio over-time. [Med-Science 2021; 10(3.000): 1026-30] |
topic |
inflammation 25-oh vitamin d chronic kidney disease d/p creatinine ratio peritoneal dialysis |
url |
http://www.ejmanager.com/fulltextpdf.php?mno=63675 |
work_keys_str_mv |
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