Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

Extracellular acidification is an important feature of tumor microenvironments but has yet to be successfully exploited in cancer therapy. The reversal of the pH gradient across the plasma membrane in cells that regulate intracellular pH (pHi) has potential to drive the selective uptake of weak acid...

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Bibliographic Details
Main Authors:	Michael P. Hay, Hong Nam Shin, Way Wua Wong, Wan Wan Sahimi, Aaron T.D. Vaz, Pooja Yadav, Robert F. Anderson, Kevin O. Hicks, William R. Wilson
Format:	Article
Language:	English
Published:	MDPI AG 2019-07-01
Series:	Molecules
Subjects:	bioreductive prodrugs benzotriazine di-oxides tumor acidosis tumor hypoxia pH-dependent partitioning radical chemistry tirapazamine SN30000 CEN-209 chlorambucil WST-1
Online Access:	https://www.mdpi.com/1420-3049/24/14/2524

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